Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR7 | P34969 | 7/20 | 0.53 |
| ▸ | HTR6 | P50406 | 6/20 | 0.53 |
| ▸ | HTR1A | P08908 | 6/20 | 0.53 |
| ▸ | HTR2A | P28223 | 1/20 | 0.53 |
| ▸ | HTR5A | P47898 | 1/20 | 0.53 |
| ▸ | HTR3A | P46098 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.44 |
| ▸ | HTR3B | O95264 | 1/20 | 0.44 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.44 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.44 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.44 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.44 |
| ▸ | HTR2B | P41595 | 3/20 | 0.40 |
| ▸ | HTR2C | P28335 | 1/20 | 0.40 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.40 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.40 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.40 |
| ▸ | CETP | P11597 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5305271 | 0.76 | HTR2C (0.40) | HTR7HTR6HTR1AHTR2AHTR5A | |
| SCHEMBL4914927 | 0.76 | HTR7 (0.73) | HTR7HTR6HTR1AHTR2AHTR5A | |
| SCHEMBL6650883 | 0.75 | HTR7 (0.59) | HTR7HTR6HTR1AHTR2AHTR5A | |
| SCHEMBL4909484 | 0.75 | HTR7 (0.59) | HTR7HTR6HTR1AHTR2AHTR5A | |
| SCHEMBL746343 | 0.74 | ALDH1A1 (0.54) | HTR7HTR6HTR1AHTR2AHTR5A | |
| SCHEMBL5366514 | 0.71 | HTR6 (0.56) | HTR7HTR6HTR1AHTR2AHTR5A | |
| SCHEMBL4909469 | 0.70 | HTR7 (0.58) | HTR7HTR6HTR1AHTR2AHTR5A | |
| SCHEMBL30146694 | 0.70 | HTR7 (0.58) | HTR7HTR6HTR1AHTR2AHTR5A | |
| SCHEMBL28618211 | 0.70 | KDM4E (0.41) | ALDH1A1LMNA | |
| SCHEMBL3759275 | 0.69 | HTR7 (1.00) | HTR7HTR6HTR1AHTR2AHTR5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1828156-A2 | N-BIARYL AND N-ARYLHETEROARYL PIPERAZINE DERIVATIVES AS MODULATORS OF THE 5HT2C RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO | Arena Pharmaceuticals, Inc. (US) | 2007-09-05 | — | — | EP | claimed |
| WO-2006065600-A2 | N-BIARYL AND N-ARYLHETEROARYL PIPERAZINE DERIVATIVES AS MODULATORS OF THE 5HT2C RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO | ARENA PHARMACEUTICALS, INC. (US) | 2006-06-22 | — | — | WO | claimed |