Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | ALDH3A1 | P30838 | 1/20 | 0.41 |
| ▸ | ALDH1A3 | P47895 | 1/20 | 0.41 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.40 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.39 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | CNR2 | P34972 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | RAD51 | Q06609 | 1/20 | 0.37 |
| ▸ | PRKDC | P78527 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3548981 | 0.80 | MAPT (0.62) | MAPTGAASMN1; SMN2MAPK1ALDH3A1 | |
| SCHEMBL4164690 | 0.73 | MAPT (0.47) | MAPTGAASMN1; SMN2MAPK1THRB | |
| SCHEMBL3546898 | 0.73 | MAPT (0.51) | MAPTSMN1; SMN2CYP1A2KDM4ERAB9A | |
| SCHEMBL23555248 | 0.72 | CRHR1 (0.44) | MAPTGAASMN1; SMN2MAPK1ALDH3A1 | |
| SCHEMBL29932002 | 0.69 | MAPT (0.46) | MAPTGAASMN1; SMN2MAPK1ALDH3A1 | |
| SCHEMBL12989805 | 0.69 | ALDH1A1 (0.40) | MAPTGAASMN1; SMN2MAPK1ALDH3A1 | |
| SCHEMBL23536336 | 0.69 | MAPT (0.46) | MAPTGAASMN1; SMN2MAPK1ALDH3A1 | |
| SCHEMBL26608200 | 0.69 | KMT2A (0.49) | MAPTMAPK1CYP1A2CYP2D6RAB9A | |
| SCHEMBL3541882 | 0.69 | MAPT (0.49) | MAPTGAASMN1; SMN2MAPK1RAB9A | |
| SCHEMBL1199782 | 0.68 | MAPT (0.45) | MAPTGAASMN1; SMN2MAPK1GPR55 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1833806-A1 | OXADIAZOLE DERIVATIVES AS DGAT INHIBITORS | AstraZeneca AB (SE) | 2007-09-19 | — | — | EP | disclosed |
| WO-2006064189-A1 | OXADIAZOLE DERIVATIVES AS DGAT INHIBITORS | ASTRAZENECA AB (SE) | 2006-06-22 | — | — | WO | disclosed |