Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOX1 | Q9Y5S8 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.39 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.39 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.39 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.39 |
| ▸ | HTR2C | P28335 | 1/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.39 |
| ▸ | DRD3 | P35462 | 1/20 | 0.39 |
| ▸ | HTR2B | P41595 | 1/20 | 0.39 |
| ▸ | MAOB | P27338 | 6/20 | 0.39 |
| ▸ | MAOA | P21397 | 4/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.38 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.36 |
| ▸ | AURKA | O14965 | 1/20 | 0.36 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.36 |
| ▸ | JAK2 | O60674 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5212917 | 0.86 | TAAR1 (0.43) | KMT2AMEN1MAOBFYNCYP19A1 | |
| SCHEMBL5256493 | 0.86 | EHMT2 (0.38) | NOX1KMT2AL3MBTL1MEN1ADRA2A | |
| SCHEMBL27906420 | 0.85 | PARK7 (0.45) | KMT2AMEN1 | |
| SCHEMBL27924324 | 0.85 | ALDH1A1 (0.44) | SLC6A2SLC6A4SIGMAR1 | |
| SCHEMBL9358633 | 0.84 | HRH3 (0.39) | SLC6A4SIGMAR1GSK3AGSK3BHRH3 | |
| SCHEMBL27924321 | 0.82 | PARK7 (0.47) | SLC6A4SIGMAR1 | |
| SCHEMBL5215900 | 0.81 | HRH1 (0.41) | NOX1KMT2AL3MBTL1MEN1ADRA2A | |
| SCHEMBL27906314 | 0.81 | KMT2A (0.35) | KMT2AL3MBTL1MEN1HRH3TAAR1 | |
| SCHEMBL5216610 | 0.73 | MAPT (0.41) | L3MBTL1SIGMAR1SMN1; SMN2 | |
| SCHEMBL27906310 | 0.69 | ALDH1A1 (0.37) | KMT2AMEN1SLC6A2SLC6A4HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1797054-A2 | ARYL-AMINO SUBSTITUTED PYRROLOPYRIMIDINE MULTI-KINASE INHIBITING COMPOUNDS | OSI Pharmaceuticals, Inc. (US) | 2007-06-20 | — | — | EP | disclosed |
| WO-2006017443-A2 | ARYL-AMINO SUBSTITUTED PYRROLOPYRIMIDINE MULTI-KINASE INHIBITING COMPOUNDS | OSI PHARMACEUTICALS, INC. (US) | 2006-02-16 | — | — | WO | disclosed |