Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 9/20 | 0.59 |
| ▸ | L3MBTL1 | Q9Y468 | 6/20 | 0.59 |
| ▸ | MPI | P34949 | 1/20 | 0.59 |
| ▸ | KDM4A | O75164 | 2/20 | 0.58 |
| ▸ | EGLN1 | Q9GZT9 | 2/20 | 0.58 |
| ▸ | KDM6B | O15054 | 1/20 | 0.58 |
| ▸ | KDM6A | O15550 | 1/20 | 0.58 |
| ▸ | TET3 | O43151 | 1/20 | 0.58 |
| ▸ | KDM4B | O94953 | 1/20 | 0.58 |
| ▸ | KDM5C | P41229 | 1/20 | 0.58 |
| ▸ | KDM4D | Q6B0I6 | 1/20 | 0.58 |
| ▸ | TET2 | Q6N021 | 1/20 | 0.58 |
| ▸ | ALKBH5 | Q6P6C2 | 1/20 | 0.58 |
| ▸ | TET1 | Q8NFU7 | 1/20 | 0.58 |
| ▸ | FTO | Q9C0B1 | 1/20 | 0.58 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.58 |
| ▸ | KDM2A | Q9Y2K7 | 1/20 | 0.58 |
| ▸ | KDM3A | Q9Y4C1 | 1/20 | 0.58 |
| ▸ | NAPRT | Q6XQN6 | 2/20 | 0.53 |
| ▸ | SLC40A1 | Q9NP59 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4033083 | 0.86 | KDM4E (0.68) | KDM4EL3MBTL1MPIKDM4AEGLN1 | |
| SCHEMBL69673 | 0.85 | KDM4E (0.77) | KDM4EL3MBTL1KDM4AEGLN1KDM6B | |
| SCHEMBL18689122 | 0.81 | KDM4E (0.62) | KDM4EL3MBTL1MPIKDM4AEGLN1 | |
| SCHEMBL11261836 | 0.81 | KDM4E (0.75) | KDM4EL3MBTL1MPIKDM4AEGLN1 | |
| SCHEMBL1126280 | 0.79 | KMT2A (0.62) | KDM4EL3MBTL1KDM4AEGLN1KDM6B | |
| SCHEMBL30503371 | 0.79 | SLC6A2 (0.59) | KDM4EL3MBTL1KDM4AEGLN1KDM6B | |
| SCHEMBL28507152 | 0.79 | KDM4E (0.59) | KDM4EL3MBTL1KDM4AEGLN1KDM6B | |
| SCHEMBL11803761 | 0.79 | SLC6A2 (0.59) | KDM4EL3MBTL1KDM4AEGLN1KDM6B | |
| SCHEMBL29848459 | 0.79 | HSP90AA1 (0.59) | KDM4EL3MBTL1KDM4AEGLN1KDM6B | |
| SCHEMBL3131493 | 0.79 | HSP90AA1 (0.59) | KDM4EL3MBTL1KDM4AEGLN1KDM6B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11053215-B2 | Heterocyclic compounds useful as Pim kinase inhibitors | INCYTE CORPORATION (US) | 2021-07-06 | — | — | US | disclosed |
| US-10450296-B2 | Heterocyclic compounds useful as Pim kinase inhibitors | INCYTE CORPORATION (US) | 2019-10-22 | — | — | US | disclosed |
| US-20180282302-A1 | HETEROCYCLIC COMPOUNDS USEFUL AS PIM KINASE INHIBITORS | INCYTE CORPORATION | 2018-10-04 | — | — | US | disclosed |
| US-9920032-B2 | Heterocyclic compounds useful as pim kinase inhibitors | INCYTE CORPORATION (US) | 2018-03-20 | — | — | US | disclosed |
| US-20170096411-A1 | HETEROCYCLIC COMPOUNDS USEFUL AS PIM KINASE INHIBITORS | INCYTE CORPORATION | 2017-04-06 | — | — | US | disclosed |
| WO-2007028789-A1 | QUINAZOLINE DERIVATIVES AS ANTIVIRAL AGENTS | ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI SPA (IT) | 2007-03-15 | — | — | WO | disclosed |
| WO-2007028789-A1 | QUINAZOLINE DERIVATIVES AS ANTIVIRAL AGENTS | ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI SPA (IT) | 2007-03-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180282302-A1 | HETEROCYCLIC COMPOUNDS USEFUL AS PIM KINASE INHIBITORS | PIM1, PIM2, PIM3 | KDM4E 1497/4885L3MBTL1 1056/4885MPI 266/4885 |
| US-11053215-B2 | Heterocyclic compounds useful as Pim kinase inhibitors | PIM1, PIM2, PIM3 | KDM4E 1497/4885L3MBTL1 1056/4885MPI 266/4885 |
| US-10450296-B2 | Heterocyclic compounds useful as Pim kinase inhibitors | PIM1, PIM2, PIM3 | KDM4E 1497/4885L3MBTL1 1056/4885MPI 266/4885 |
| US-20170096411-A1 | HETEROCYCLIC COMPOUNDS USEFUL AS PIM KINASE INHIBITORS | PIM1, PIM2, PIM3 | KDM4E 1497/4885L3MBTL1 1056/4885MPI 266/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.