Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESRRA | P11474 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | CYP17A1 | P05093 | 3/20 | 0.32 |
| ▸ | PHGDH | O43175 | 2/20 | 0.32 |
| ▸ | ALPL | P05186 | 1/20 | 0.32 |
| ▸ | CA9 | Q16790 | 1/20 | 0.32 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.31 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.31 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.31 |
| ▸ | GPR142 | Q7Z601 | 2/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | DCTPP1 | Q9H773 | 1/20 | 0.31 |
| ▸ | BACE1 | P56817 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5313526 | 0.80 | NOTUM (0.34) | ESRRAMAPTUSP2KDM4EGAA | |
| SCHEMBL5308125 | 0.75 | ESRRA (0.43) | ESRRAMAPTUSP2NPC1RAB9A | |
| SCHEMBL5306918 | 0.73 | MAPT (0.46) | ESRRAMAPTUSP2NPC1RAB9A | |
| SCHEMBL5333351 | 0.71 | CYP17A1 (0.37) | MAPTNPC1RAB9ACYP17A1PHGDH | |
| SCHEMBL31617619 | 0.70 | MAPT (0.41) | ESRRAMAPTNPC1RAB9ACYP11B1 | |
| SCHEMBL5306913 | 0.69 | CDK2 (0.40) | MAPTNPC1RAB9AGPR142KDM4E | |
| SCHEMBL1911837 | 0.69 | NPC1 (0.58) | MAPTNPC1RAB9AAAK1 | |
| SCHEMBL5306577 | 0.69 | CYP11B1 (0.41) | ESRRAMAPTUSP2NPC1RAB9A | |
| SCHEMBL19105638 | 0.69 | GSK3B (0.41) | PHGDHCYP11B1CYP11B2GPR142GAA | |
| SCHEMBL5304381 | 0.68 | NTRK1 (0.51) | MAPTRAB9AGPR142 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007034279-A2 | C3A ANTAGONISTS AND PHARMACEUTICAL COMPOSITIONS THEREOF | PFIZER PRODUCTS INC. (US) | 2007-03-29 | — | — | WO | claimed |
| WO-2007034279-A2 | C3A ANTAGONISTS AND PHARMACEUTICAL COMPOSITIONS THEREOF | PFIZER PRODUCTS INC. (US) | 2007-03-29 | — | — | WO | disclosed |