Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 3/20 | 0.52 |
| ▸ | DRD3 | P35462 | 3/20 | 0.52 |
| ▸ | MAOB | P27338 | 4/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.49 |
| ▸ | HTR1A | P08908 | 4/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.48 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.48 |
| ▸ | HTR7 | P34969 | 1/20 | 0.48 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.48 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | GLA | P06280 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29391217 | 0.94 | DRD2 (0.56) | DRD2DRD3MAOBALDH1A1HTR1A | |
| SCHEMBL17844904 | 0.94 | DRD2 (0.56) | DRD2DRD3MAOBALDH1A1HTR1A | |
| SCHEMBL829637 | 0.92 | ALDH1A1 (0.57) | DRD2DRD3MAOBALDH1A1HTR1A | |
| SCHEMBL29944565 | 0.92 | ALDH1A1 (0.57) | DRD2DRD3MAOBALDH1A1HTR1A | |
| SCHEMBL12263981 | 0.91 | MAOB (0.57) | DRD2DRD3MAOBALDH1A1HTR1A | |
| SCHEMBL29263692 | 0.91 | MAOB (0.57) | DRD2DRD3MAOBALDH1A1HTR1A | |
| SCHEMBL29659287 | 0.87 | KMT2A (0.57) | DRD2DRD3ALDH1A1HTR1AMEN1 | |
| SCHEMBL578012 | 0.87 | KMT2A (0.57) | DRD2DRD3ALDH1A1HTR1AMEN1 | |
| SCHEMBL22123837 | 0.85 | ALDH1A1 (0.49) | DRD2DRD3MAOBALDH1A1HTR1A | |
| SCHEMBL25030669 | 0.85 | DRD2 (0.49) | DRD2DRD3MAOBALDH1A1HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1737463-A1 | PYRIMIDINES WITH TIE2 (TEK) ACTIVITY | AstraZeneca AB (SE) | 2007-01-03 | — | — | EP | disclosed |
| WO-2005060970-A1 | PYRIMIDINES WITH TIE2 (TEK) ACTIVITY | ASTRAZENECA AB (SE) | 2005-07-07 | — | — | WO | disclosed |