Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MGAM | O43451 | 1/20 | 0.61 |
| ▸ | CFTR | P13569 | 1/20 | 0.49 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.47 |
| ▸ | CSNK1G2 | P78368 | 1/20 | 0.47 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.47 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.47 |
| ▸ | MAP4K5 | Q9Y4K4 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.46 |
| ▸ | BCAT1 | P54687 | 1/20 | 0.46 |
| ▸ | TOP2A | P11388 | 1/20 | 0.46 |
| ▸ | TOP2B | Q02880 | 1/20 | 0.46 |
| ▸ | KDR | P35968 | 1/20 | 0.46 |
| ▸ | DPP4 | P27487 | 1/20 | 0.45 |
| ▸ | HPGDS | O60760 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | MITF | O75030 | 1/20 | 0.45 |
| ▸ | XBP1 | P17861 | 1/20 | 0.45 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2625196 | 0.87 | MGAM (0.65) | MGAMCFTRMAP4K4CSNK1G2CLK4 | |
| SCHEMBL27784603 | 0.82 | MGAM (0.67) | MGAMCFTRMAP4K4CSNK1G2CLK4 | |
| SCHEMBL10350097 | 0.80 | MGAM (0.59) | MGAMCFTRMAP4K4CSNK1G2CLK4 | |
| SCHEMBL23372 | 0.78 | MGAM (0.71) | MGAMCFTRMAP4K4CSNK1G2CLK4 | |
| SCHEMBL530761 | 0.78 | MGAM (0.71) | MGAMCFTRMAP4K4CSNK1G2CLK4 | |
| SCHEMBL29684771 | 0.78 | MGAM (0.71) | MGAMCFTRMAP4K4CSNK1G2CLK4 | |
| SCHEMBL29362497 | 0.78 | MGAM (0.71) | MGAMCFTRMAP4K4CSNK1G2CLK4 | |
| SCHEMBL7371232 | 0.78 | MGAM (0.76) | MGAMCFTRMAP4K4CSNK1G2CLK4 | |
| SCHEMBL15309423 | 0.78 | MGAM (0.56) | MGAMCFTRMAP4K4CSNK1G2CLK4 | |
| SCHEMBL12043740 | 0.77 | HPGDS (0.67) | MGAMCYP1A2BCAT1KDRHPGDS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2597955-A1 | QUINOLINE DERIVATIVES AND MELK INHIBITORS CONTAINING THE SAME | OncoTherapy Science, Inc. (JP) | 2013-06-05 | — | — | EP | disclosed |
| WO-2012016082-A1 | QUINOLINE DERIVATIVES AND MELK INHIBITORS CONTAINING THE SAME | ONCOTHERAPY SCIENCE, INC. (JP) | 2012-02-02 | — | — | WO | disclosed |