Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSL | P07711 | 3/20 | 0.58 |
| ▸ | CTSS | P25774 | 2/20 | 0.58 |
| ▸ | SIRT2 | Q8IXJ6 | 14/20 | 0.54 |
| ▸ | SIRT1 | Q96EB6 | 10/20 | 0.54 |
| ▸ | SIRT3 | Q9NTG7 | 10/20 | 0.54 |
| ▸ | CTSB | P07858 | 1/20 | 0.54 |
| ▸ | CTSK | P43235 | 1/20 | 0.54 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8236608 | 1.00 | CTSL (0.58) | CTSLCTSSSIRT2SIRT1SIRT3 | |
| SCHEMBL5298109 | 0.90 | SIRT2 (0.54) | CTSLCTSSSIRT2SIRT1SIRT3 | |
| SCHEMBL22599593 | 0.86 | CTSL (0.70) | CTSLCTSSSIRT2SIRT1SIRT3 | |
| SCHEMBL8750804 | 0.85 | CTSL (0.56) | CTSLCTSSSIRT2SIRT1SIRT3 | |
| SCHEMBL8766104 | 0.84 | CTSL (0.76) | CTSLCTSSSIRT2SIRT1SIRT3 | |
| SCHEMBL5300239 | 0.84 | SIRT2 (0.59) | CTSLCTSSSIRT2SIRT1SIRT3 | |
| SCHEMBL8245500 | 0.84 | SIRT2 (0.59) | CTSLCTSSSIRT2SIRT1SIRT3 | |
| SCHEMBL8243061 | 0.84 | POLB (0.50) | CTSLCTSSSIRT2SIRT1CTSK | |
| SCHEMBL5309251 | 0.84 | POLB (0.50) | CTSLCTSSSIRT2SIRT1CTSK | |
| SCHEMBL8767026 | 0.83 | CTSL (0.77) | CTSLCTSSSIRT2SIRT1SIRT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007027742-A2 | SMALL MOLECULE INTEGRIN α2βl/GPIa-IIa ANTAGONISTS | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2007-03-08 | — | — | WO | claimed |
| WO-2007027742-A2 | SMALL MOLECULE INTEGRIN α2βl/GPIa-IIa ANTAGONISTS | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2007-03-08 | — | — | WO | disclosed |