Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 1/20 | 0.51 |
| ▸ | SMYD3 | Q9H7B4 | 5/20 | 0.50 |
| ▸ | TNKS | O95271 | 1/20 | 0.47 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.44 |
| ▸ | CD38 | P28907 | 4/20 | 0.44 |
| ▸ | RORC | P51449 | 1/20 | 0.44 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.43 |
| ▸ | GRM5 | P41594 | 1/20 | 0.43 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.43 |
| ▸ | HTR4 | Q13639 | 1/20 | 0.43 |
| ▸ | PIM1 | P11309 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7019900 | 0.85 | CD38 (0.57) | P2RX7TNKSACKR3CD38GRM5 | |
| SCHEMBL30363652 | 0.84 | P2RX7 (0.53) | P2RX7SMYD3TNKSACKR3CD38 | |
| SCHEMBL25417634 | 0.82 | SMYD3 (0.55) | P2RX7SMYD3TNKSCD38 | |
| SCHEMBL30336165 | 0.82 | SMYD3 (0.55) | P2RX7SMYD3TNKSCD38 | |
| SCHEMBL29998657 | 0.82 | P2RX7 (0.51) | P2RX7SMYD3TNKSCD38RORC | |
| Hydrochloric Acid SCHEMBL29998785 | 0.81 | P2RX7 (0.50) | P2RX7SMYD3TNKSCD38RORC | |
| SCHEMBL29745057 | 0.81 | GRM5 (0.67) | SMYD3GRM5 | |
| SCHEMBL29048262 | 0.81 | P2RX7 (0.53) | P2RX7TNKSACKR3CD38RORC | |
| SCHEMBL19132865 | 0.80 | CD38 (0.61) | P2RX7SMYD3TNKSACKR3CD38 | |
| SCHEMBL25053103 | 0.80 | SMYD3 (0.48) | SMYD3ACKR3CD38GRM5PIM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1993129-A | Thienopyrimidines and thiazolopyrimidines for use in medicine | ASTRAZENECA AB (SE) | 2007-07-04 | — | — | CN | disclosed |
| EP-1755610-A2 | THIENOPYRIMIDINES AND THIAZOLOPYRIMIDINES FOR USE IN MEDICINE | AstraZeneca AB (SE) | 2007-02-28 | — | — | EP | disclosed |
| WO-2005117890-A2 | THIENOPYRIMIDINES AND THIAZOLOPYRIMIDINES FOR USE IN MEDICINE | ASTRAZENECA AB (SE) | 2005-12-15 | — | — | WO | disclosed |