Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.77 |
| ▸ | LMNA | P02545 | 4/20 | 0.71 |
| ▸ | ALDH1A1 | P00352 | 10/20 | 0.69 |
| ▸ | HTT | P42858 | 8/20 | 0.68 |
| ▸ | RECQL | P46063 | 1/20 | 0.63 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.59 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.59 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.58 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.58 |
| ▸ | USP2 | O75604 | 5/20 | 0.56 |
| ▸ | MEN1 | O00255 | 3/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.56 |
| ▸ | TSHR | P16473 | 3/20 | 0.55 |
| ▸ | GAA | P10253 | 1/20 | 0.55 |
| ▸ | HPGD | P15428 | 2/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30198068 | 1.00 | KDM4E (0.77) | KDM4ELMNAALDH1A1HTTRECQL | |
| SCHEMBL2383886 | 0.87 | KDM4E (1.00) | KDM4ELMNAALDH1A1HTTRECQL | |
| SCHEMBL25721191 | 0.87 | KDM4E (0.58) | KDM4ELMNAALDH1A1HTTRECQL | |
| SCHEMBL38660347 | 0.85 | KDM4E (0.86) | KDM4ELMNAALDH1A1HTTRECQL | |
| SCHEMBL24054558 | 0.84 | ALDH1A1 (0.76) | KDM4ELMNAALDH1A1HTTRECQL | |
| SCHEMBL30198363 | 0.84 | ALDH1A1 (0.76) | KDM4ELMNAALDH1A1HTTRECQL | |
| SCHEMBL24054938 | 0.84 | ALDH1A1 (0.63) | KDM4ELMNAALDH1A1HTTRECQL | |
| SCHEMBL29280468 | 0.83 | HSP90AA1 (0.64) | KDM4ELMNAALDH1A1HTTSMN1; SMN2 | |
| SCHEMBL29943809 | 0.83 | ALDH1A1 (0.76) | KDM4ELMNAALDH1A1HTTRECQL | |
| SCHEMBL27031265 | 0.83 | ALDH1A1 (0.76) | KDM4ELMNAALDH1A1HTTRECQL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230203003-A1 | Notch Inhibitors and Uses Thereof | STEMSYNERGY THERAPEUTICS, INC. | 2023-06-29 | — | — | US | disclosed |
| US-20230203003-A1 | Notch Inhibitors and Uses Thereof | STEMSYNERGY THERAPEUTICS, INC. | 2023-06-29 | — | — | US | disclosed |
| US-20230203003-A1 | Notch Inhibitors and Uses Thereof | STEMSYNERGY THERAPEUTICS, INC. | 2023-06-29 | — | — | US | disclosed |
| CN-115836056-A | NOTCH inhibitors and uses thereof | STEMSYNERGY疗法有限责任公司 | 2023-03-21 | — | — | CN | disclosed |
| WO-2021237112-A1 | NOTCH INHIBITORS AND USES THEREOF | STEMSYNERGY THERAPEUTICS, INC. (US) | 2021-11-25 | — | — | WO | disclosed |
| US-9757369-B2 | Heterocyclic GSK-3 allosteric modulators | CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS (CSIC) (ES) | 2017-09-12 | — | — | US | disclosed |
| US-20170196850-A1 | Heterocyclic GSK-3 Allosteric Modulators | CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS (CSIC) (ES) | 2017-07-13 | — | — | US | disclosed |
| EP-2769720-B1 | HETEROCYCLIC GSK-3 ALLOSTERIC MODULATORS | CONSEJO SUPERIOR DE INVESTIG CIENTÍFICAS (CSIC) (ES) | 2017-03-29 | — | — | EP | disclosed |
| US-9585879-B2 | Heterocyclic GSK-3 allosteric modulators | CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS (CSIC) (ES) | 2017-03-07 | — | — | US | disclosed |
| US-20160113918-A1 | Heterocyclic GSK-3 Allosteric Modulators | CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS (CSIC) (ES) | 2016-04-28 | — | — | US | disclosed |
| US-9193688-B2 | Heterocyclic GSK-3 allosteric modulators | CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS (ES) | 2015-11-24 | — | — | US | disclosed |
| US-20150057311-A1 | Heterocyclic GSK-3 Allosteric Modulators | CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS (CSIC) (ES) | 2015-02-26 | — | — | US | disclosed |
| EP-2769720-A1 | HETEROCYCLIC GSK-3 ALLOSTERIC MODULATORS | Consejo Superior De Investigaciones Científicas (CSIC) (ES) | 2014-08-27 | — | — | EP | disclosed |
| WO-2007038571-A2 | PROLYL HYDROXYLASE ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 2007-04-05 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230203003-A1 | Notch Inhibitors and Uses Thereof | NOTCH1, NOTCH2, NOTCH4 | KDM4E 751/4885LMNA 3567/4885ALDH1A1 2288/4885 |
| US-20170196850-A1 | Heterocyclic GSK-3 Allosteric Modulators | GSK3B, GSK3A, GSKIP | KDM4E 878/4885LMNA 2874/4885ALDH1A1 3820/4885 |
| US-20160113918-A1 | Heterocyclic GSK-3 Allosteric Modulators | GSK3B, GSK3A, GSKIP | KDM4E 878/4885LMNA 2874/4885ALDH1A1 3820/4885 |
| US-20150057311-A1 | Heterocyclic GSK-3 Allosteric Modulators | GSK3B, GSK3A, GSKIP | KDM4E 878/4885LMNA 2874/4885ALDH1A1 3820/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.