Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 1/20 | 0.36 |
| ▸ | EGFR | P00533 | 1/20 | 0.35 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.35 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 3/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | BRD4 | O60885 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.35 |
| ▸ | PPARG | P37231 | 1/20 | 0.35 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.35 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.35 |
| ▸ | SLC6A5 | Q9Y345 | 1/20 | 0.35 |
| ▸ | SGMS2 | Q8NHU3 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5308788 | 1.00 | MAOB (0.36) | MAOBEGFRERBB2ENPP2MEN1 | |
| SCHEMBL5308915 | 0.92 | BRD4 (0.38) | MAOBMEN1KMT2AALDH1A1BRD4 | |
| SCHEMBL5308913 | 0.92 | BRD4 (0.38) | MAOBMEN1KMT2AALDH1A1BRD4 | |
| SCHEMBL5313885 | 0.89 | NFE2L2 (0.42) | MAPTADORA1 | |
| SCHEMBL5313884 | 0.89 | NFE2L2 (0.42) | MAPTADORA1 | |
| SCHEMBL5310553 | 0.84 | MEN1 (0.40) | MAOBMEN1KMT2AALDH1A1LMNA | |
| SCHEMBL5310556 | 0.84 | MEN1 (0.40) | MAOBMEN1KMT2AALDH1A1LMNA | |
| SCHEMBL5308207 | 0.83 | DHODH (0.34) | MAOBENPP2MEN1KMT2AALDH1A1 | |
| SCHEMBL5310704 | 0.82 | CASR (0.40) | MAOBMEN1KMT2AALDH1A1LMNA | |
| SCHEMBL5307926 | 0.82 | ALDH1A1 (0.38) | MAOBMEN1KMT2AALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007044796-A2 | PYRIDAZINONE COMPOUNDS AS CALCILYTICS | NPS PHARMACEUTICALS, INC. (US) | 2007-04-19 | — | — | WO | disclosed |