Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 2/20 | 0.48 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.46 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.44 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.44 |
| ▸ | ERCC1 | P07992 | 1/20 | 0.41 |
| ▸ | ERCC4 | Q92889 | 1/20 | 0.41 |
| ▸ | MIF | P14174 | 1/20 | 0.41 |
| ▸ | P2RX7 | Q99572 | 3/20 | 0.40 |
| ▸ | TYR | P14679 | 1/20 | 0.39 |
| ▸ | HTR2C | P28335 | 1/20 | 0.39 |
| ▸ | HTR2B | P41595 | 1/20 | 0.39 |
| ▸ | PIM1 | P11309 | 1/20 | 0.39 |
| ▸ | DYRK2 | Q92630 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3568253 | 0.84 | P2RX7 (0.53) | MAOBEPHX2NR1H4P2RX7 | |
| SCHEMBL4338177 | 0.82 | AKR1B1 (0.53) | EPHX2NR1H4ERCC1ERCC4P2RX7 | |
| SCHEMBL3883601 | 0.81 | ERCC1 (0.54) | EPHX2NR1H4ERCC1ERCC4P2RX7 | |
| SCHEMBL2965399 | 0.81 | AKR1B1 (0.55) | EPHX2NR1H4P2RX7 | |
| SCHEMBL26672084 | 0.79 | EPHX2 (0.43) | EPHX2NR1H4P2RX7 | |
| SCHEMBL28357135 | 0.78 | CYP1A2 (0.51) | EPHX2NR1H4P2RX7 | |
| SCHEMBL30496735 | 0.77 | MAOB (0.41) | MAOBCHRNA7EPHX2NR1H4ERCC1 | |
| SCHEMBL17198958 | 0.77 | MAOB (0.41) | MAOBCHRNA7EPHX2NR1H4ERCC1 | |
| SCHEMBL3559618 | 0.77 | CHRM4 (0.42) | EPHX2NR1H4ERCC1ERCC4P2RX7 | |
| SCHEMBL4894133 | 0.77 | NQO2 (0.49) | MAOBCHRNA7EPHX2NR1H4MIF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007035154-A1 | NOVEL N-PYRAZINIL-PHENYLSULFONAMIDE DERIVATIVES AS CHEMOKINE RECEPTOR MODULATORS FOR USE IN THE TREATMENT OF ASTHMA | ASTRAZENECA AB (SE) | 2007-03-29 | — | — | WO | disclosed |