Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERCC1 | P07992 | 1/20 | 0.54 |
| ▸ | ERCC4 | Q92889 | 1/20 | 0.54 |
| ▸ | AKR1B1 | P15121 | 3/20 | 0.52 |
| ▸ | P2RX7 | Q99572 | 8/20 | 0.47 |
| ▸ | HTR2C | P28335 | 1/20 | 0.47 |
| ▸ | HTR2B | P41595 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | MMP2 | P08253 | 1/20 | 0.45 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.44 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.44 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.43 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.43 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7976991 | 0.85 | CYP2C9 (0.54) | ERCC1ERCC4AKR1B1P2RX7HTR2C | |
| SCHEMBL7976988 | 0.85 | ERCC1 (0.52) | ERCC1ERCC4AKR1B1P2RX7HTR2C | |
| SCHEMBL20446357 | 0.84 | ERCC1 (0.51) | ERCC1ERCC4AKR1B1ALDH1A1EPHX2 | |
| SCHEMBL23565573 | 0.83 | ERCC1 (0.58) | ERCC1ERCC4AKR1B1P2RX7HTR2C | |
| SCHEMBL3460045 | 0.83 | EPHX2 (0.54) | ERCC1ERCC4AKR1B1ALDH1A1ROCK2 | |
| SCHEMBL3568253 | 0.82 | P2RX7 (0.53) | AKR1B1P2RX7ALDH1A1EPHX2NR1H4 | |
| SCHEMBL697972 | 0.82 | ALDH1A1 (0.63) | ERCC1ERCC4P2RX7ALDH1A1EPHX2 | |
| SCHEMBL13647246 | 0.82 | ERCC1 (0.50) | ERCC1ERCC4AKR1B1P2RX7HTR2C | |
| SCHEMBL18887626 | 0.82 | ERCC1 (0.50) | ERCC1ERCC4P2RX7HTR2CHTR2B | |
| SCHEMBL7934896 | 0.82 | ERCC1 (0.57) | ERCC1ERCC4AKR1B1P2RX7HTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2013163-A1 | TETRASUBSTITUTED UREAS AS MODULATORS OF 11-BETA HYDROXYL STEROID DEHYDROGENASE TYPE 1 | Incyte Corporation (US) | 2009-01-14 | — | — | EP | disclosed |
| US-20070293529-A1 | Tetrasubstituted ureas as modulators of 11-beta hydroxyl steroid dehydrogenase type 1 | INCYTE CORPORATION | 2007-12-20 | — | — | US | disclosed |
| WO-2007130898-A1 | TETRASUBSTITUTED UREAS AS MODULATORS OF 11-β HYDROXYL STEROID DEHYDROGENASE TYPE 1 | INCYTE CORPORATION (US) | 2007-11-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070293529-A1 | Tetrasubstituted ureas as modulators of 11-beta hydroxyl steroid dehydrogenase type 1 | HSD11B1, HSD17B1, HSD17B11 | ERCC1 3109/4885ERCC4 3107/4885AKR1B1 101/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.