Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGDS | O60760 | 2/20 | 0.44 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.36 |
| ▸ | IMPDH1 | P20839 | 1/20 | 0.36 |
| ▸ | CCR1 | P32246 | 2/20 | 0.33 |
| ▸ | CCR5 | P51681 | 2/20 | 0.33 |
| ▸ | CCR8 | P51685 | 2/20 | 0.33 |
| ▸ | SLC40A1 | Q9NP59 | 1/20 | 0.33 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.32 |
| ▸ | METAP2 | P50579 | 1/20 | 0.32 |
| ▸ | PARP1 | P09874 | 2/20 | 0.32 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.31 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.31 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.31 |
| ▸ | MAP3K14 | Q99558 | 1/20 | 0.31 |
| ▸ | VCP | P55072 | 1/20 | 0.31 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.31 |
| ▸ | CHUK | O15111 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11910642 | 0.82 | HPGDS (0.59) | HPGDSIMPDH2IMPDH1CCR1CCR5 | |
| SCHEMBL30492619 | 0.82 | HPGDS (0.59) | HPGDSIMPDH2IMPDH1CCR1CCR5 | |
| SCHEMBL5310535 | 0.77 | HPGDS (0.46) | HPGDSIMPDH2IMPDH1CCR1CCR5 | |
| SCHEMBL5314035 | 0.75 | HPGDS (0.43) | HPGDSIMPDH2IMPDH1CYP19A1HTT | |
| SCHEMBL1994732 | 0.74 | CCR1 (0.57) | HPGDSCCR1CCR5CCR8SLC40A1 | |
| SCHEMBL30492680 | 0.74 | CCR1 (0.57) | HPGDSCCR1CCR5CCR8SLC40A1 | |
| SCHEMBL5251543 | 0.72 | ALDH1A1 (0.43) | TRPA1 | |
| SCHEMBL5260083 | 0.71 | HPGDS (0.43) | HPGDSIMPDH2IMPDH1CYP19A1HTT | |
| SCHEMBL5260088 | 0.71 | HPGDS (0.43) | HPGDSIMPDH2IMPDH1HTT | |
| SCHEMBL11910090 | 0.69 | HPGDS (0.47) | HPGDSCCR1CCR5CCR8HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1242382-B1 | TRICYCLIC PROTEIN KINASE INHIBITORS | WYETH CORP (US) | 2007-02-07 | — | — | EP | claimed |