Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | MELK | Q14680 | 10/20 | 0.45 |
| ▸ | FYN | P06241 | 1/20 | 0.43 |
| ▸ | TRIM58 | Q8NG06 | 2/20 | 0.43 |
| ▸ | RAD52 | P43351 | 3/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | UHRF1 | Q96T88 | 1/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.42 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL529115 | 0.92 | MELK (0.51) | KMT2AKDM4EMEN1GAAMELK | |
| SCHEMBL15191190 | 0.88 | KMT2A (0.64) | KMT2AKDM4EMEN1GAARAD52 | |
| SCHEMBL530888 | 0.87 | KCNH2 (0.54) | KMT2AKDM4EMEN1GAAMELK | |
| SCHEMBL10282210 | 0.85 | MAPT (0.50) | KMT2AKDM4EMEN1GAARAD52 | |
| SCHEMBL529183 | 0.85 | MELK (0.52) | KMT2AKDM4EMEN1GAAMELK | |
| Hydrochloric Acid SCHEMBL529682 | 0.84 | MAPT (0.49) | KMT2AKDM4EMEN1GAARAD52 | |
| SCHEMBL17450160 | 0.84 | MELK (0.60) | MELK | |
| SCHEMBL530078 | 0.83 | KMT2A (0.44) | KMT2AKDM4EMEN1GAAMELK | |
| SCHEMBL529253 | 0.83 | MAPK1 (0.58) | KMT2AKDM4EMEN1GAARAD52 | |
| SCHEMBL530333 | 0.83 | MELK (0.52) | KMT2AKDM4EMEN1GAAMELK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2597955-A1 | QUINOLINE DERIVATIVES AND MELK INHIBITORS CONTAINING THE SAME | OncoTherapy Science, Inc. (JP) | 2013-06-05 | — | — | EP | disclosed |
| WO-2012016082-A1 | QUINOLINE DERIVATIVES AND MELK INHIBITORS CONTAINING THE SAME | ONCOTHERAPY SCIENCE, INC. (JP) | 2012-02-02 | — | — | WO | disclosed |