Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MELK | Q14680 | 16/20 | 0.52 |
| ▸ | RAF1 | P04049 | 1/20 | 0.47 |
| ▸ | BRAF | P15056 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | FYN | P06241 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10282015 | 0.89 | KMT2A (0.61) | MELKKDM4EMEN1GAAKMT2A | |
| SCHEMBL10282210 | 0.88 | MAPT (0.50) | KDM4EMEN1GAAKMT2A | |
| Hydrochloric Acid SCHEMBL529682 | 0.87 | MAPT (0.49) | KDM4EMEN1GAAKMT2A | |
| SCHEMBL529115 | 0.86 | MELK (0.51) | MELKKDM4EMEN1GAAKMT2A | |
| SCHEMBL531008 | 0.85 | KMT2A (0.46) | MELKKDM4EMEN1GAAKMT2A | |
| SCHEMBL530888 | 0.84 | KCNH2 (0.54) | MELKBRAFKDM4EMEN1GAA | |
| SCHEMBL15191230 | 0.83 | MELK (0.49) | MELKRAF1BRAF | |
| SCHEMBL529253 | 0.80 | MAPK1 (0.58) | KDM4EMEN1GAAKMT2A | |
| SCHEMBL529687 | 0.80 | CSF1R (0.47) | MELKKDM4EMEN1GAAKMT2A | |
| SCHEMBL530085 | 0.79 | KMT2A (0.50) | KDM4EMEN1GAAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2597955-A1 | QUINOLINE DERIVATIVES AND MELK INHIBITORS CONTAINING THE SAME | OncoTherapy Science, Inc. (JP) | 2013-06-05 | — | — | EP | disclosed |
| WO-2012016082-A1 | QUINOLINE DERIVATIVES AND MELK INHIBITORS CONTAINING THE SAME | ONCOTHERAPY SCIENCE, INC. (JP) | 2012-02-02 | — | — | WO | disclosed |