Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASR | P41180 | 9/20 | 0.43 |
| ▸ | NR1I2 | O75469 | 5/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | GNRHR | P30968 | 3/20 | 0.37 |
| ▸ | TP53 | P04637 | 2/20 | 0.35 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5310559 | 0.85 | CASR (0.57) | CASRNR1I2GNRHR | |
| SCHEMBL5311242 | 0.83 | CASR (0.49) | CASRNR1I2GNRHR | |
| SCHEMBL5313138 | 0.79 | CASR (0.53) | CASRNR1I2USP2TP53 | |
| SCHEMBL5311483 | 0.78 | CASR (0.48) | CASRNR1I2 | |
| SCHEMBL5308152 | 0.78 | CASR (0.58) | CASRNR1I2 | |
| SCHEMBL5309910 | 0.78 | ALPL (0.38) | CASRNR1I2GNRHR | |
| SCHEMBL5309367 | 0.77 | CASR (0.46) | CASRNR1I2 | |
| SCHEMBL5311941 | 0.77 | GNRHR (0.40) | CASRGNRHR | |
| SCHEMBL5308600 | 0.75 | CASR (0.52) | CASR | |
| SCHEMBL5308899 | 0.75 | GNRHR (0.35) | CASRALDH1A1TSHRGNRHRKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007044796-A2 | PYRIDAZINONE COMPOUNDS AS CALCILYTICS | NPS PHARMACEUTICALS, INC. (US) | 2007-04-19 | — | — | WO | disclosed |
| WO-2007044796-A2 | PYRIDAZINONE COMPOUNDS AS CALCILYTICS | NPS PHARMACEUTICALS, INC. (US) | 2007-04-19 | — | — | WO | disclosed |