Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | CLK1 | P49759 | 1/20 | 0.39 |
| ▸ | CDK9 | P50750 | 1/20 | 0.39 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.39 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.39 |
| ▸ | DYRK2 | Q92630 | 1/20 | 0.39 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.39 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | KDM4C | Q9H3R0 | 3/20 | 0.38 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.38 |
| ▸ | KDM5A | P29375 | 2/20 | 0.37 |
| ▸ | KDM5B | Q9UGL1 | 2/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5310779 | 0.81 | CLK1 (0.38) | ALDH1A1CLK1CDK9CDK5DYRK1A | |
| SCHEMBL937935 | 0.75 | POLB (0.43) | POLBALDH1A1TP53CLK1CDK9 | |
| SCHEMBL8075339 | 0.74 | POLB (0.68) | POLBALDH1A1TP53KMT2ATSHR | |
| SCHEMBL6840297 | 0.72 | KDM4E (0.56) | POLBALDH1A1CLK1CDK9CDK5 | |
| SCHEMBL4235452 | 0.72 | NPC1 (0.50) | ALDH1A1TP53MEN1KMT2AKDM4E | |
| SCHEMBL13177150 | 0.69 | PBRM1 (0.47) | ALDH1A1TP53CLK1CDK9CDK5 | |
| SCHEMBL937934 | 0.68 | ALDH1A1 (0.40) | POLBALDH1A1CLK1CDK9CDK5 | |
| SCHEMBL8952892 | 0.67 | ALDH1A1 (0.47) | ALDH1A1KDM4CPBRM1KDM5AKDM5B | |
| SCHEMBL7863162 | 0.67 | ALDH1A1 (0.47) | ALDH1A1KDM4CPBRM1KDM5AKDM5B | |
| SCHEMBL18758064 | 0.67 | ALDH1A1 (0.47) | POLBALDH1A1CLK1DYRK1ACLK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1863771-A2 | BENZAZOLE DERIVATIVES, COMPOSITIONS, AND METHODS OF USE AS B-SECRETASE INHIBITORS | Transtech Pharma, Inc. (US) | 2007-12-12 | — | — | EP | claimed |
| WO-2006099379-A2 | BENZAZOLE DERIVATIVES, COMPOSITIONS, AND METHODS OF USE AS B-SECRETASE INHIBITORS | TRANSTECH PHARMA, INC. (US) | 2006-09-21 | — | — | WO | claimed |