Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CLK1 | P49759 | 1/20 | 0.38 |
| ▸ | CDK9 | P50750 | 1/20 | 0.38 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.38 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.38 |
| ▸ | DYRK2 | Q92630 | 1/20 | 0.38 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.38 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | KDM4C | Q9H3R0 | 3/20 | 0.36 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.36 |
| ▸ | KDM5A | P29375 | 2/20 | 0.36 |
| ▸ | KDM5B | Q9UGL1 | 2/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.35 |
| ▸ | FLT1 | P17948 | 1/20 | 0.35 |
| ▸ | KDR | P35968 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | PRKAG1 | P54619 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5310773 | 0.81 | POLB (0.44) | CLK1CDK9CDK5DYRK1ADYRK2 | |
| SCHEMBL6840297 | 0.70 | KDM4E (0.56) | CLK1CDK9CDK5DYRK1ADYRK2 | |
| SCHEMBL937935 | 0.69 | POLB (0.43) | CLK1CDK9CDK5DYRK1ADYRK2 | |
| SCHEMBL31393783 | 0.68 | NPSR1 (0.45) | ALDH1A1MEN1KMT2ARAB9AL3MBTL1 | |
| SCHEMBL28146557 | 0.68 | TNKS (0.42) | TSHRKMT2ARAB9AL3MBTL1 | |
| SCHEMBL13177150 | 0.68 | PBRM1 (0.47) | CLK1CDK9CDK5DYRK1ADYRK2 | |
| SCHEMBL4235452 | 0.68 | NPC1 (0.50) | ALDH1A1MEN1KMT2AKDM4ERAB9A | |
| SCHEMBL18757922 | 0.67 | ALDH1A1 (0.46) | ALDH1A1KDM4CPBRM1KDM5AKDM5B | |
| SCHEMBL8952892 | 0.66 | ALDH1A1 (0.47) | ALDH1A1KDM4CPBRM1KDM5AKDM5B | |
| SCHEMBL7863162 | 0.66 | ALDH1A1 (0.47) | ALDH1A1KDM4CPBRM1KDM5AKDM5B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1863771-A2 | BENZAZOLE DERIVATIVES, COMPOSITIONS, AND METHODS OF USE AS B-SECRETASE INHIBITORS | Transtech Pharma, Inc. (US) | 2007-12-12 | — | — | EP | claimed |
| WO-2006099379-A2 | BENZAZOLE DERIVATIVES, COMPOSITIONS, AND METHODS OF USE AS B-SECRETASE INHIBITORS | TRANSTECH PHARMA, INC. (US) | 2006-09-21 | — | — | WO | claimed |