Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GBA1 | P04062 | 1/20 | 0.50 |
| ▸ | HRH1 | P35367 | 4/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | SCN1A | P35498 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.47 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.47 |
| ▸ | SLC6A2 | P23975 | 4/20 | 0.42 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.42 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.41 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.41 |
| ▸ | HTR1A | P08908 | 2/20 | 0.40 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5651523 | 0.84 | SLC6A2 (0.50) | GBA1HRH1LMNACYP2D6MEN1 | |
| SCHEMBL11861949 | 0.83 | HRH1 (0.53) | GBA1HRH1LMNACYP2D6MEN1 | |
| Hydrochloric Acid SCHEMBL11843236 | 0.81 | HRH1 (0.51) | GBA1HRH1LMNACYP2D6MEN1 | |
| SCHEMBL14701445 | 0.79 | SLC6A4 (0.54) | MEN1KMT2ASLC6A2TAAR1SLC6A4 | |
| SCHEMBL9432081 | 0.79 | SLC6A2 (0.42) | LMNACYP2D6KMT2ASLC6A2TAAR1 | |
| SCHEMBL28021430 | 0.79 | HRH1 (0.56) | GBA1HRH1LMNACYP2D6MEN1 | |
| SCHEMBL5650003 | 0.77 | GBA1 (0.45) | GBA1HRH1LMNACYP2D6MEN1 | |
| SCHEMBL7488409 | 0.76 | GBA1 (0.56) | GBA1HRH1LMNACYP2D6SLC6A2 | |
| SCHEMBL27643138 | 0.75 | LMNA (0.49) | GBA1HRH1LMNACYP2D6SLC6A2 | |
| SCHEMBL5649395 | 0.75 | GBA1 (0.46) | GBA1HRH1LMNACYP2D6MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2627650-A2 | N-PHENYL IMIDAZOLE CARBOXAMIDE INHIBITORS OF 3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE-1 | Merck Sharp & Dohme Corp. (US) | 2013-08-21 | — | — | EP | disclosed |
| WO-2011149874-A2 | N-PHENYL IMIDAZOLE CARBOXAMIDE INHIBITORS OF 3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE-1 | SCHERING CORPORATION (US) | 2011-12-01 | — | — | WO | disclosed |
| CN-1021328-C | PROCESS FOR PREPARING PYRIDAZINAMINE DERIVATIVES | JANSSEN PHARMACEUTICA NV (BE) | 1993-06-23 | — | — | CN | disclosed |
| CN-1033274-A | The preparation method of new Pyridazinyl amine derivative | JANSSEN PHARMACEUTICA NV (BE) | 1989-06-07 | — | — | CN | disclosed |