Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 1/20 | 0.51 |
| ▸ | NPC1 | O15118 | 3/20 | 0.48 |
| ▸ | RAB9A | P51151 | 3/20 | 0.48 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.47 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.46 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.46 |
| ▸ | DRD2 | P14416 | 1/20 | 0.45 |
| ▸ | DRD4 | P21917 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.44 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.44 |
| ▸ | BACE1 | P56817 | 1/20 | 0.44 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.43 |
| ▸ | CRHBP | P24387 | 1/20 | 0.43 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.43 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.43 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28250048 | 0.93 | RAB9A (0.51) | NPC1RAB9ATRPV1PTGS1CRHBP | |
| SCHEMBL28250047 | 0.91 | NPC1 (0.57) | NPC1RAB9AHDAC2TRPV1PTGS1 | |
| SCHEMBL28536704 | 0.90 | CTDSP1 (0.53) | NPC1RAB9ACTDSP1MAPT | |
| SCHEMBL28250190 | 0.81 | POLB (0.54) | NPC1RAB9AHDAC2CYP3A4 | |
| SCHEMBL28250050 | 0.80 | KCNK3 (0.55) | NPC1RAB9AMAPT | |
| SCHEMBL28908852 | 0.78 | POLB (0.53) | NPC1RAB9ATMEM97SIGMAR1MAPT | |
| SCHEMBL28250847 | 0.77 | NPC1 (0.53) | NPC1RAB9AMAPT | |
| SCHEMBL28456845 | 0.77 | TRPV1 (0.54) | NPC1RAB9ATRPV1PTGS1 | |
| SCHEMBL14714456 | 0.77 | NPC1 (0.56) | NPC1RAB9AHDAC2CTDSP1DRD2 | |
| SCHEMBL6416083 | 0.76 | NPC1 (0.60) | NPC1RAB9ACTDSP1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007044574-A2 | PHARMACEUTICAL COMPOSITIONS, METHODS OF PREPARATION THEREOF, AND METHODS OF TREATMENT | TRANSTECH PHARMA, INC. (US) | 2007-04-19 | — | — | WO | disclosed |
| US-20070082952-A1 | Pharmaceutical compositions, methods of preparation thereof, and methods of treatment | TRANSTECH PHARMA, INC. | 2007-04-12 | — | — | US | disclosed |