Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.48 |
| ▸ | PDE1A | P54750 | 2/20 | 0.43 |
| ▸ | PDE1B | Q01064 | 2/20 | 0.43 |
| ▸ | PDE1C | Q14123 | 2/20 | 0.43 |
| ▸ | TP53 | P04637 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 5/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | HPGD | P15428 | 3/20 | 0.39 |
| ▸ | PLAT | P00750 | 1/20 | 0.38 |
| ▸ | GNRHR | P30968 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5311895 | 0.89 | GNRHR (0.42) | KDM4EPDE1APDE1BPDE1CTSHR | |
| SCHEMBL5311130 | 0.86 | KDM4E (0.42) | KDM4EPDE1APDE1BPDE1CTP53 | |
| SCHEMBL5311949 | 0.84 | CASR (0.47) | KDM4EUSP2POLBPDE4APDE4B | |
| SCHEMBL5311530 | 0.82 | GNRHR (0.49) | GNRHR | |
| SCHEMBL5310470 | 0.82 | KDM4E (0.41) | KDM4ETP53MAPTGNRHRCYP3A4 | |
| SCHEMBL5315640 | 0.80 | BRD4 (0.40) | KDM4ETSHRMAPTALDH1A1CYP1A2 | |
| SCHEMBL5313086 | 0.77 | GNRHR (0.40) | KDM4EMAPTGNRHRTHRB | |
| SCHEMBL5311941 | 0.76 | GNRHR (0.40) | MAPTGNRHR | |
| SCHEMBL5313183 | 0.76 | PDE1A (0.43) | KDM4EPDE1APDE1BPDE1CTP53 | |
| SCHEMBL5313180 | 0.76 | PDE1A (0.43) | KDM4EPDE1APDE1BPDE1CTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007044796-A2 | PYRIDAZINONE COMPOUNDS AS CALCILYTICS | NPS PHARMACEUTICALS, INC. (US) | 2007-04-19 | — | — | WO | disclosed |
| WO-2007044796-A2 | PYRIDAZINONE COMPOUNDS AS CALCILYTICS | NPS PHARMACEUTICALS, INC. (US) | 2007-04-19 | — | — | WO | disclosed |