Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GNRHR | P30968 | 4/20 | 0.42 |
| ▸ | CASR | P41180 | 5/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | PDE1A | P54750 | 1/20 | 0.41 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.41 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | DPP4 | P27487 | 1/20 | 0.37 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.37 |
| ▸ | STK10 | O94804 | 1/20 | 0.37 |
| ▸ | SLK | Q9H2G2 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5311530 | 0.93 | GNRHR (0.49) | GNRHRCASR | |
| SCHEMBL5310470 | 0.91 | KDM4E (0.41) | GNRHRCASRKDM4EL3MBTL1TAAR1 | |
| SCHEMBL5311552 | 0.89 | KDM4E (0.48) | GNRHRKDM4EPDE1APDE1BPDE1C | |
| SCHEMBL5313086 | 0.89 | GNRHR (0.40) | GNRHRCASRKDM4EL3MBTL1TAAR1 | |
| SCHEMBL5311941 | 0.88 | GNRHR (0.40) | GNRHRCASRP2RX7 | |
| SCHEMBL5310463 | 0.87 | GNRHR (0.43) | GNRHRCASRKDM4EL3MBTL1TAAR1 | |
| SCHEMBL5308386 | 0.86 | CASR (0.54) | CASR | |
| SCHEMBL5311052 | 0.85 | CASR (0.43) | GNRHRCASRKDM4EL3MBTL1TAAR1 | |
| SCHEMBL5307935 | 0.85 | TP53 (0.44) | GNRHRCASRKDM4EL3MBTL1TAAR1 | |
| SCHEMBL5307986 | 0.83 | CASR (0.45) | GNRHRCASR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007044796-A2 | PYRIDAZINONE COMPOUNDS AS CALCILYTICS | NPS PHARMACEUTICALS, INC. (US) | 2007-04-19 | — | — | WO | disclosed |