Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE1A | P54750 | 1/20 | 0.43 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.43 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.43 |
| ▸ | SLC37A4 | O43826 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | NFE2L2 | Q16236 | 2/20 | 0.38 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.36 |
| ▸ | PLAT | P00750 | 1/20 | 0.36 |
| ▸ | FYN | P06241 | 1/20 | 0.35 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5313180 | 1.00 | PDE1A (0.43) | PDE1APDE1BPDE1CSLC37A4TSHR | |
| SCHEMBL5313219 | 0.87 | LMNA (0.38) | PDE1APDE1BPDE1CSLC37A4MAPT | |
| SCHEMBL5313217 | 0.87 | LMNA (0.38) | PDE1APDE1BPDE1CSLC37A4MAPT | |
| SCHEMBL5311055 | 0.84 | SLC37A4 (0.37) | PDE1APDE1BPDE1CSLC37A4MAPT | |
| SCHEMBL5307655 | 0.82 | NFE2L2 (0.41) | PDE1APDE1BPDE1CNFE2L2 | |
| SCHEMBL5313885 | 0.82 | NFE2L2 (0.42) | PDE1APDE1BPDE1CSLC37A4TSHR | |
| SCHEMBL5313884 | 0.82 | NFE2L2 (0.42) | PDE1APDE1BPDE1CSLC37A4TSHR | |
| SCHEMBL5308913 | 0.78 | BRD4 (0.38) | KDM4EALDH1A1HPGDGLA | |
| SCHEMBL14541733 | 0.77 | FAAH (0.41) | PDE1APDE1BPDE1CTSHRMAPT | |
| SCHEMBL5308113 | 0.76 | NFE2L2 (0.39) | MAPTNFE2L2KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007044796-A2 | PYRIDAZINONE COMPOUNDS AS CALCILYTICS | NPS PHARMACEUTICALS, INC. (US) | 2007-04-19 | — | — | WO | disclosed |