Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.58 |
| ▸ | LMNA | P02545 | 7/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.58 |
| ▸ | GAA | P10253 | 3/20 | 0.58 |
| ▸ | HTT | P42858 | 3/20 | 0.58 |
| ▸ | MAPT | P10636 | 9/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.52 |
| ▸ | MEN1 | O00255 | 5/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.52 |
| ▸ | HPGD | P15428 | 5/20 | 0.49 |
| ▸ | ALOX12 | P18054 | 3/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | XBP1 | P17861 | 1/20 | 0.49 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.49 |
| ▸ | SHBG | P04278 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2548769 | 0.93 | KDM4E (0.60) | KDM4ELMNASMN1; SMN2GAAHTT | |
| SCHEMBL2546358 | 0.73 | MAPT (0.70) | KDM4ELMNASMN1; SMN2GAAHTT | |
| SCHEMBL17985011 | 0.72 | KDM4E (0.60) | KDM4ELMNASMN1; SMN2GAAHTT | |
| Iodide SCHEMBL6263376 | 0.71 | KDM4E (0.59) | KDM4ELMNASMN1; SMN2GAAHTT | |
| SCHEMBL9417920 | 0.71 | HTT (0.56) | KDM4ELMNASMN1; SMN2GAAHTT | |
| SCHEMBL18677516 | 0.71 | KAT8 (0.51) | LMNAHTTMAPTALDH1A1MEN1 | |
| Bicarbonate SCHEMBL28733244 | 0.71 | CYP1A2 (0.61) | KDM4ELMNASMN1; SMN2HTTALDH1A1 | |
| SCHEMBL17120036 | 0.71 | MEN1 (0.58) | LMNASMN1; SMN2HTTMAPTALDH1A1 | |
| SCHEMBL787524 | 0.71 | KDM4E (0.50) | KDM4EMAPTHPGDHSD17B10 | |
| SCHEMBL8170546 | 0.70 | TSHR (0.46) | KDM4ESMN1; SMN2GAAHTTMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070148185-A1 | Novel therapeutic target for protozoal diseases | VIRGINIA POLYTECHNIC INSTITUTE AND STATE UNIVERSITY | 2007-06-28 | — | — | US | claimed |
| WO-2007047579-A2 | A NOVEL THERAPEUTIC TARGET FOR PROTOZOAL DISEASES | VIRGINIA TECH INTELLECTUAL PROPERTIES, INC. (US) | 2007-04-26 | — | — | WO | claimed |