Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.70 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.70 |
| ▸ | PKM | P14618 | 1/20 | 0.59 |
| ▸ | LMNA | P02545 | 6/20 | 0.57 |
| ▸ | GAA | P10253 | 3/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.57 |
| ▸ | MEN1 | O00255 | 2/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.57 |
| ▸ | GFER | P55789 | 1/20 | 0.57 |
| ▸ | RAB9A | P51151 | 5/20 | 0.56 |
| ▸ | TP53 | P04637 | 2/20 | 0.56 |
| ▸ | RECQL | P46063 | 1/20 | 0.56 |
| ▸ | ESR1 | P03372 | 2/20 | 0.55 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.55 |
| ▸ | SHBG | P04278 | 1/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.55 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.54 |
| ▸ | NPC1 | O15118 | 3/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3703417 | 0.85 | KDM4E (0.53) | MAPTKDM4EPKMLMNAGAA | |
| SCHEMBL17985011 | 0.84 | KDM4E (0.60) | MAPTKDM4ELMNAGAAALDH1A1 | |
| Iodide SCHEMBL6263376 | 0.83 | KDM4E (0.59) | MAPTKDM4ELMNAGAAALDH1A1 | |
| SCHEMBL11655292 | 0.80 | KDM4E (0.51) | MAPTKDM4EPKMLMNAGAA | |
| SCHEMBL146018 | 0.76 | ESR1 (0.80) | MAPTKDM4ELMNAGAAALDH1A1 | |
| SCHEMBL30497946 | 0.76 | ESR1 (0.80) | MAPTKDM4ELMNAGAAALDH1A1 | |
| SCHEMBL22362717 | 0.75 | LMNA (0.63) | MAPTKDM4ELMNAGAAALDH1A1 | |
| SCHEMBL2548769 | 0.75 | KDM4E (0.60) | MAPTKDM4EPKMLMNAGAA | |
| SCHEMBL29017606 | 0.74 | RAB9A (0.73) | MAPTKDM4EGAAALDH1A1KMT2A | |
| SCHEMBL5311650 | 0.73 | KDM4E (0.58) | MAPTKDM4ELMNAGAAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11236053-B2 | NADPH oxidase inhibitors and uses thereof | EMORY UNIVERSITY (US) | 2022-02-01 | — | — | US | disclosed |
| US-20200270214-A1 | NADPH Oxidase Inhibitors and Uses Thereof | UNIV EMORY (US) | 2020-08-27 | — | — | US | disclosed |
| US-9408826-B2 | Isoflavone anti-viral compounds | Kineta, Inc. (US) | 2016-08-09 | — | — | US | disclosed |
| US-9408826-B2 | Isoflavone anti-viral compounds | Kineta, Inc. (US) | 2016-08-09 | — | — | US | disclosed |
| US-9408826-B2 | Isoflavone anti-viral compounds | Kineta, Inc. (US) | 2016-08-09 | — | — | US | disclosed |
| EP-2560652-A2 | ANTI-VIRAL COMPOUNDS | Kineta, Inc. (US) | 2013-02-27 | — | — | EP | disclosed |
| US-20110262482-A1 | ANTI-VIRAL COMPOUNDS | Kineta, Inc. (US) | 2011-10-27 | — | — | US | disclosed |
| US-20110262482-A1 | ANTI-VIRAL COMPOUNDS | Kineta, Inc. (US) | 2011-10-27 | — | — | US | disclosed |
| US-20110262482-A1 | ANTI-VIRAL COMPOUNDS | Kineta, Inc. (US) | 2011-10-27 | — | — | US | disclosed |
| WO-2011133728-A2 | ANTI-VIRAL COMPOUNDS | Kineta, Inc. (US) | 2011-10-27 | — | — | WO | disclosed |
| WO-2011133728-A2 | ANTI-VIRAL COMPOUNDS | Kineta, Inc. (US) | 2011-10-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200270214-A1 | NADPH Oxidase Inhibitors and Uses Thereof | NOX1, NOX3, NOX5 | MAPT 2818/4885KDM4E 2768/4885PKM 1792/4885 |
| US-20110262482-A1 | ANTI-VIRAL COMPOUNDS | MAVS, EIF2AK2, IRF3 | MAPT 3520/4885KDM4E 2601/4885PKM 3932/4885 |
| US-11236053-B2 | NADPH oxidase inhibitors and uses thereof | NOX1, NOX3, NOX5 | MAPT 2818/4885KDM4E 2768/4885PKM 1792/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.