Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DDR1 | Q08345 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | EGLN1 | Q9GZT9 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.34 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.33 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.33 |
| ▸ | KCNE1 | P15382 | 1/20 | 0.33 |
| ▸ | CCR1 | P32246 | 1/20 | 0.33 |
| ▸ | KCNQ1 | P51787 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 3/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.32 |
| ▸ | SLC16A3 | O15427 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5252169 | 0.85 | DDR1 (0.40) | DDR1KMT2AEGLN1EGLN2EPHX2 | |
| SCHEMBL5304414 | 0.82 | DDR1 (0.38) | DDR1KMT2AALDH1A1EPHX2TRPV1 | |
| SCHEMBL5129686 | 0.82 | KCNA5 (0.42) | DDR1KMT2AEGLN1EGLN2EPHX2 | |
| SCHEMBL2203635 | 0.81 | DDR1 (0.42) | DDR1EPHX2KCNE1CCR1KCNQ1 | |
| SCHEMBL5128894 | 0.79 | DDR1 (0.41) | DDR1EGLN1EGLN2EPHX2KCNE1 | |
| Trifluoroacetic Acid SCHEMBL5127989 | 0.71 | DDR1 (0.38) | DDR1EGLN1EGLN2EPHX2 | |
| SCHEMBL5258740 | 0.71 | DDR1 (0.38) | DDR1EPHX2TRPV1SMN1; SMN2POLB | |
| SCHEMBL6645834 | 0.71 | DDR1 (0.38) | DDR1EPHX2TRPV1KCNE1CCR1 | |
| SCHEMBL13998917 | 0.71 | DDR1 (0.36) | DDR1EGLN1ALDH1A1EPHX2P2RX7 | |
| SCHEMBL5251193 | 0.71 | KCNE1 (0.47) | KMT2AEGLN1ALDH1A1KCNE1CCR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1441734-B1 | DIHYDROXYPYRIMIDINE CARBOXAMIDE INHIBITORS OF HIV INTEGRASE | ANGELETTI P IST RICHERCHE BIO (IT) | 2007-02-28 | — | — | EP | claimed |