Known targets — ChEMBL curated mechanism
ADORA1ADORA2AADORA2BADORA3PDE3APDE3BPDE4APDE4BPDE4CPDE4D
The experimentally established mechanism targets of Tyrosine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA3 known ✓ | P0DMS8 | 1/20 | 0.57 |
| ▸ | SLC7A5 | Q01650 | 3/20 | 0.86 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.61 |
| ▸ | ALPI | P09923 | 1/20 | 0.61 |
| ▸ | PKM | P14618 | 1/20 | 0.61 |
| ▸ | XIAP | P98170 | 1/20 | 0.61 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.57 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.57 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.57 |
| ▸ | USP2 | O75604 | 1/20 | 0.57 |
| ▸ | EGFR | P00533 | 1/20 | 0.57 |
| ▸ | LCK | P06239 | 1/20 | 0.57 |
| ▸ | FYN | P06241 | 1/20 | 0.57 |
| ▸ | HTR2A | P28223 | 1/20 | 0.57 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.57 |
| ▸ | RECQL | P46063 | 1/20 | 0.57 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.57 |
| ▸ | TPH1 | P17752 | 1/20 | 0.53 |
| ▸ | GRB2 | P62993 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tyrosine SCHEMBL2764615 | 1.00 | SLC7A5 (0.86) | SLC7A5PTGS1ALPIPKMXIAP | |
| Tyrosine SCHEMBL1857843 | 1.00 | SLC7A5 (0.86) | SLC7A5PTGS1ALPIPKMXIAP | |
| Tyrosine SCHEMBL27035831 | 1.00 | SLC7A5 (0.86) | SLC7A5PTGS1ALPIPKMXIAP | |
| Tyrosine SCHEMBL4287074 | 1.00 | SLC7A5 (0.86) | SLC7A5PTGS1ALPIPKMXIAP | |
| Tyrosine SCHEMBL3039720 | 1.00 | SLC7A5 (0.86) | SLC7A5PTGS1ALPIPKMXIAP | |
| Tyrosine SCHEMBL21250225 | 1.00 | SLC7A5 (0.86) | SLC7A5PTGS1ALPIPKMXIAP | |
| Tyrosine SCHEMBL8896891 | 0.95 | SLC7A5 (0.77) | SLC7A5PTGS1ALPIPKMXIAP | |
| Tyrosine SCHEMBL1067115 | 0.95 | SLC7A5 (0.77) | SLC7A5PTGS1ALPIPKMXIAP | |
| Tyrosine SCHEMBL9729320 | 0.95 | SLC7A5 (0.77) | SLC7A5PTGS1ALPIPKMXIAP | |
| Tyrosine SCHEMBL25308979 | 0.94 | SLC7A5 (0.75) | SLC7A5PTGS1ALPIPKMXIAP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 361 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118325994-A | Natto oligopeptide, preparation method thereof and application thereof in thrombolysis and blood pressure reduction | 大连深蓝肽科技研发有限公司 | 2024-07-12 | — | — | CN | claimed |
| WO-2024140670-A1 | CONJUGATE AND USES THEREOF | FULL-LIFE TECHNOLOGIES HK LIMITED (CN) | 2024-07-04 | — | — | WO | claimed |
| WO-2023066932-A1 | STABILIZED MHC MOLECULES | IMMATICS BIOTECHNOLOGIES GMBH (DE) | 2023-04-27 | — | — | WO | claimed |
| CN-109879988-B | Free radical photopolymerization dark curing initiation system and preparation method thereof | 海南师范大学 | 2022-08-26 | — | — | CN | claimed |
| CN-113912524-A | Polypeptide compound containing sulfamide and synthesis method thereof | 华东师范大学 | 2022-01-11 | — | — | CN | claimed |
| CN-111511360-A | Phosphorylcholine-deglutition promoting peptide conjugates for treating ocular inflammation | 塔斯制药公司 | 2020-08-07 | — | — | CN | claimed |
| EP-3544992-A1 | G-PROTEIN-COUPLED RECEPTOR INTERNAL SENSORS | The Regents of The University of California (US) | 2019-10-02 | — | — | EP | claimed |
| US-20190032045-A1 | Microarray Based Multiplex Pathogen Analysis and Uses Thereof | PathogenDX Inc (US) | 2019-01-31 | — | — | US | claimed |
| US-20190032046-A1 | Microarray Based Multiplex Pathogen Analysis and Uses Thereof | PathogenDX Inc (US) | 2019-01-31 | — | — | US | claimed |
| US-20180251758-A1 | Microarray Based Multiplex Pathogen Analysis and Uses Thereof | PathogenDX Inc (US) | 2018-09-06 | — | — | US | claimed |
| US-20030036507-A1 | Regulation of neuroendocrine and paracrine responses to stress. | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2003-02-20 | — | — | US | claimed |
| WO-2002074326-A2 | UROCORTIN-III AND USES THEREOF | RESEARCH DEVELOPMENT FOUNDATION (US) | 2002-09-26 | — | — | WO | claimed |
| US-6440691-B1 | AIDS VIRICIDES | LARGE SCALE BIOLOGY CORPORATION | 2002-08-27 | — | — | US | claimed |
| WO-2002046238-A2 | RATIONALLY DESIGNED ANTIBODIES | ALEXION PHARMACEUTICALS, INC. (US) | 2002-06-13 | — | — | WO | claimed |
| US-20020039726-A1 | Melanins with improved ability to inhibit HIV replication | GARGER STEVEN (US) | 2002-04-04 | — | — | US | claimed |
| US-6300057-B1 | TREATING HIV INFECTIONS BY ADMINISTERING A THERAPEUTIC DOSE OF SYNTHESIZED MELANIN CONTAINING AN ANIONIC GROUP OF SULFATES AND SULFONYLS; NONTOXIC THERAPY OF HUMAN IMMUNODEFICIENCY VIRUS | LARGE SCALE BIOLOGY CORPORATION | 2001-10-09 | — | — | US | claimed |
| EP-1095652-A2 | Melanins with improved ability to inhibit HIV replication | Biosource Technologies, Inc. (US) | 2001-05-02 | — | — | EP | claimed |
| EP-1014964-A1 | MELANINS WITH IMPROVED ABILITY TO INHIBIT HIV REPLICATION | Biosource Technologies, Inc. (US) | 2000-07-05 | — | — | EP | claimed |
| US-5972677-A | ALLOW FOR INTERNAL INITIATION OF MRNA CAP-INDEPENDENT TRANSLATION. | Tischfield, J. | 1999-10-26 | — | — | US | claimed |
| WO-1998034606-A1 | MELANINS WITH IMPROVED ABILITY TO INHIBIT HIV REPLICATION | BIOSOURCE TECHNOLOGIES, INC. (US) | 1998-08-13 | — | — | WO | claimed |