Known targets — ChEMBL curated mechanism
ADORA1ADORA2AADORA2BADORA3PDE3APDE3BPDE4APDE4BPDE4CPDE4D
The experimentally established mechanism targets of Tyrosine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA3 known ✓ | P0DMS8 | 1/20 | 0.53 |
| ▸ | SLC7A5 | Q01650 | 4/20 | 0.77 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.71 |
| ▸ | ALPI | P09923 | 1/20 | 0.71 |
| ▸ | PKM | P14618 | 1/20 | 0.71 |
| ▸ | XIAP | P98170 | 1/20 | 0.71 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.54 |
| ▸ | SLC15A1 | P46059 | 1/20 | 0.53 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.53 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.53 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | USP2 | O75604 | 1/20 | 0.53 |
| ▸ | EGFR | P00533 | 1/20 | 0.53 |
| ▸ | LCK | P06239 | 1/20 | 0.53 |
| ▸ | FYN | P06241 | 1/20 | 0.53 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.53 |
| ▸ | HTR2A | P28223 | 1/20 | 0.53 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.53 |
| ▸ | RECQL | P46063 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tyrosine SCHEMBL1067115 | 1.00 | SLC7A5 (0.77) | SLC7A5PTGS1ALPIPKMXIAP | |
| Tyrosine SCHEMBL9729320 | 1.00 | SLC7A5 (0.77) | SLC7A5PTGS1ALPIPKMXIAP | |
| Tyrosine SCHEMBL27035831 | 0.95 | SLC7A5 (0.86) | SLC7A5PTGS1ALPIPKMXIAP | |
| Tyrosine SCHEMBL531185 | 0.95 | SLC7A5 (0.86) | SLC7A5PTGS1ALPIPKMXIAP | |
| Tyrosine SCHEMBL2764615 | 0.95 | SLC7A5 (0.86) | SLC7A5PTGS1ALPIPKMXIAP | |
| Tyrosine SCHEMBL3039720 | 0.95 | SLC7A5 (0.86) | SLC7A5PTGS1ALPIPKMXIAP | |
| Tyrosine SCHEMBL1857843 | 0.95 | SLC7A5 (0.86) | SLC7A5PTGS1ALPIPKMXIAP | |
| Tyrosine SCHEMBL4287074 | 0.95 | SLC7A5 (0.86) | SLC7A5PTGS1ALPIPKMXIAP | |
| Tyrosine SCHEMBL21250225 | 0.95 | SLC7A5 (0.86) | SLC7A5PTGS1ALPIPKMXIAP | |
| Tyrosine SCHEMBL27542577 | 0.94 | SLC7A5 (0.69) | SLC7A5PTGS1ALPIPKMXIAP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108872571-B | Thioflavine T-based immunoassay method | 国家纳米科学中心 | 2023-05-23 | — | — | CN | claimed |
| CN-110898230-B | Triclosan-based nano-antibiotic hydrogel and preparation method and application thereof | 中国医学科学院放射医学研究所 | 2022-11-22 | — | — | CN | claimed |
| CN-113559054-A | Active oxygen scavenging/responding allosteric self-assembly hydrogel and application thereof | 南京工业大学 | 2021-10-29 | — | — | CN | claimed |
| US-11033522-B2 | Free amino acid preparation and uses thereof | SCOTT DAVID C (US) | 2021-06-15 | — | — | US | claimed |
| CN-110898230-A | Triclosan-based nano-antibiotic hydrogel and preparation method and application thereof | 中国医学科学院放射医学研究所 | 2020-03-24 | — | — | CN | claimed |
| US-20180042879-A1 | FREE AMINO ACID PREPARATION AND USES THEREOF | SCOTT DAVID C (US) | 2018-02-15 | — | — | US | claimed |
| CN-108872571-B | Thioflavine T-based immunoassay method | 国家纳米科学中心 | 2023-05-23 | — | — | CN | disclosed |
| CN-110898230-B | Triclosan-based nano-antibiotic hydrogel and preparation method and application thereof | 中国医学科学院放射医学研究所 | 2022-11-22 | — | — | CN | disclosed |
| CN-113559054-A | Active oxygen scavenging/responding allosteric self-assembly hydrogel and application thereof | 南京工业大学 | 2021-10-29 | — | — | CN | disclosed |
| CN-110898230-A | Triclosan-based nano-antibiotic hydrogel and preparation method and application thereof | 中国医学科学院放射医学研究所 | 2020-03-24 | — | — | CN | disclosed |
| CN-1837231-A | Immunomodulatory steroids, in particular the hemihydrate of 16, alpha-bromoepiandrosterone | HOLLIS EDEN PHARMACEUTICALS (US) | 2006-09-27 | — | — | CN | disclosed |
| EP-0663953-A4 | PHAGEMIDS COEXPRESSING A SURFACE RECEPTOR AND A SURFACE HETEROLOGOUS PROTEIN. | SCRIPPS RESEARCH INST (US) | 1997-05-02 | — | — | EP | disclosed |
| EP-0663953-A1 | PHAGEMIDS COEXPRESSING A SURFACE RECEPTOR AND A SURFACE HETEROLOGOUS PROTEIN | THE SCRIPPS RESEARCH INSTITUTE (US) | 1995-07-26 | — | — | EP | disclosed |
| WO-1994005781-A1 | PHAGEMIDS COEXPRESSING A SURFACE RECEPTOR AND A SURFACE HETEROLOGOUS PROTEIN | THE SCRIPPS RESEARCH INSTITUTE (US) | 1994-03-17 | — | — | WO | disclosed |
| WO-1992019647-A1 | INTEGRIN ALPHA SUBUNIT CYTOPLASMIC DOMAIN POLYPEPTIDES, ANTIBODIES AND METHODS | THE SCRIPPS RESEARCH INSTITUTE (US) | 1992-11-12 | — | — | WO | disclosed |