Known targets — ChEMBL curated mechanism
ADORA1ADORA2AADORA2BADORA3PDE3APDE3BPDE4APDE4BPDE4CPDE4D
The experimentally established mechanism targets of Tyrosine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA3 known ✓ | P0DMS8 | 1/20 | 0.57 |
| ▸ | SLC7A5 | Q01650 | 3/20 | 0.86 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.61 |
| ▸ | ALPI | P09923 | 1/20 | 0.61 |
| ▸ | PKM | P14618 | 1/20 | 0.61 |
| ▸ | XIAP | P98170 | 1/20 | 0.61 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.57 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.57 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.57 |
| ▸ | USP2 | O75604 | 1/20 | 0.57 |
| ▸ | EGFR | P00533 | 1/20 | 0.57 |
| ▸ | LCK | P06239 | 1/20 | 0.57 |
| ▸ | FYN | P06241 | 1/20 | 0.57 |
| ▸ | HTR2A | P28223 | 1/20 | 0.57 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.57 |
| ▸ | RECQL | P46063 | 1/20 | 0.57 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.57 |
| ▸ | TPH1 | P17752 | 1/20 | 0.53 |
| ▸ | GRB2 | P62993 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tyrosine SCHEMBL2764615 | 1.00 | SLC7A5 (0.86) | SLC7A5PTGS1ALPIPKMXIAP | |
| Tyrosine SCHEMBL1857843 | 1.00 | SLC7A5 (0.86) | SLC7A5PTGS1ALPIPKMXIAP | |
| Tyrosine SCHEMBL27035831 | 1.00 | SLC7A5 (0.86) | SLC7A5PTGS1ALPIPKMXIAP | |
| Tyrosine SCHEMBL4287074 | 1.00 | SLC7A5 (0.86) | SLC7A5PTGS1ALPIPKMXIAP | |
| Tyrosine SCHEMBL21250225 | 1.00 | SLC7A5 (0.86) | SLC7A5PTGS1ALPIPKMXIAP | |
| Tyrosine SCHEMBL531185 | 1.00 | SLC7A5 (0.86) | SLC7A5PTGS1ALPIPKMXIAP | |
| Tyrosine SCHEMBL8896891 | 0.95 | SLC7A5 (0.77) | SLC7A5PTGS1ALPIPKMXIAP | |
| Tyrosine SCHEMBL1067115 | 0.95 | SLC7A5 (0.77) | SLC7A5PTGS1ALPIPKMXIAP | |
| Tyrosine SCHEMBL9729320 | 0.95 | SLC7A5 (0.77) | SLC7A5PTGS1ALPIPKMXIAP | |
| Tyrosine SCHEMBL25308979 | 0.94 | SLC7A5 (0.75) | SLC7A5PTGS1ALPIPKMXIAP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 87 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20190032045-A1 | Microarray Based Multiplex Pathogen Analysis and Uses Thereof | PathogenDX Inc (US) | 2019-01-31 | — | — | US | claimed |
| US-20190032046-A1 | Microarray Based Multiplex Pathogen Analysis and Uses Thereof | PathogenDX Inc (US) | 2019-01-31 | — | — | US | claimed |
| US-20180251758-A1 | Microarray Based Multiplex Pathogen Analysis and Uses Thereof | PathogenDX Inc (US) | 2018-09-06 | — | — | US | claimed |
| CN-105018446-B | The thinner of syrup in cellulose exoglucanase CBH I mutant and Corn Fuel Ethanol fermenting and producing | 南京天凯生物技术股份有限公司 | 2017-11-14 | — | — | CN | claimed |
| CN-105018446-A | Mutant of cellulose exocellobiohydrolase CBH I and viscosity reducer of syrup in corn fuel ethanol fermentation production | NANJING TIANKAI BIOTECHNOLOGY CO LTD | 2015-11-04 | — | — | CN | claimed |
| WO-2008118786-A1 | METHODS AND BIOMARKERS FOR DETECTING NANOPARTICLE EXPOSURE | HOUSTON ADVANCED RESEARCH CENTER (US) | 2008-10-02 | — | — | WO | claimed |
| CN-1684738-A | Use of cytokine synthesis inhibitors for the treatment of dry eye disorders | ALCON INC (CH) | 2005-10-19 | — | — | CN | claimed |
| US-11920188-B2 | Combinatorial microarray assay for clade variant detection | Eggers Frederick Henry (US) | 2024-03-05 | — | — | US | disclosed |
| US-20230391832-A1 | COMPOSITIONS COMPRISING AAV-BINDING POLYPEPTIDES AND METHODS OF USING THE SAME | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2023-12-07 | — | — | US | disclosed |
| WO-2023212694-A2 | COMPOSITIONS COMPRISING AAV-BINDING POLYPEPTIDES AND METHODS OF USING THE SAME | DONALDSON COMPANY, INC. (US) | 2023-11-02 | — | — | WO | disclosed |
| US-20230320970-A1 | Skin Care Compositions | COLGATE-PALMOLIVE COMPANY (US) | 2023-10-12 | — | — | US | disclosed |
| EP-4257113-A1 | SKIN CARE COMPOSITIONS COMPRISING VITAMIN E AND VITAMIN B3 | Colgate-Palmolive Company (US) | 2023-10-11 | — | — | EP | disclosed |
| US-11781133-B2 | Microarray based multiplex pathogen analysis and uses thereof | PATHOGENDX, INC. (US) | 2023-10-10 | — | — | US | disclosed |
| CN-1333822-A | Subtilase enzymes of the subgroups I-S1 and I-S2 having additional amino acid residues in the active site loop region | VONOZYMES AS (DK) | 2002-01-30 | — | — | CN | disclosed |
| CN-1303263-A | Topital delivery system for active agents | JOHNSON & JOHNSON CONSUMER (US) | 2001-07-11 | — | — | CN | disclosed |
| WO-2001044461-A1 | HOXC13 TRANSGENIC MICE EXHIBITING HAIR LOSS AND ICHTHYOSIS-LIKE SYNDROME | MUSC FOUNDATION FOR RESEARCH DEVELOPMENT (US) | 2001-06-21 | — | — | WO | disclosed |
| CN-1279062-A | Foamable oily gel composition | JOHNSON & JOHNSON CONSUMER (US) | 2001-01-10 | — | — | CN | disclosed |
| EP-1017820-A2 | BANANA PROTEINS, DNA, AND DNA REGULATORY ELEMENTS ASSOCIATED WITH FRUIT DEVELOPMENT | BOYCE THOMPSON INSTITUTE FOR PLANT RESEARCH, INC. (US) | 2000-07-12 | — | — | EP | disclosed |
| WO-1999015668-A2 | BANANA PROTEINS, DNA, AND DNA REGULATORY ELEMENTS ASSOCIATED WITH FRUIT DEVELOPMENT | BOYCE THOMPSON INSTITUTE FOR PLANT RESEARCH, INC. (US) | 1999-04-01 | — | — | WO | disclosed |
| CN-1151761-A | Subtilisin BPN' variants with reduced adsorption and increased hydrolysis | PROCTER & GAMBLE (US) | 1997-06-11 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230320970-A1 | Skin Care Compositions | TTPA, NQO1, ADH4 | ADORA3 3530/4885SLC7A5 762/4885PTGS1 562/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.