Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 11/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 8/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 7/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | ATM | Q13315 | 1/20 | 0.49 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.49 |
| ▸ | CCNE2 | O96020 | 2/20 | 0.49 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.49 |
| ▸ | CDK2 | P24941 | 2/20 | 0.49 |
| ▸ | CDK9 | P50750 | 2/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | GFER | P55789 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 7/20 | 0.48 |
| ▸ | RAB9A | P51151 | 5/20 | 0.48 |
| ▸ | NPC1 | O15118 | 4/20 | 0.48 |
| ▸ | PKM | P14618 | 2/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 6/20 | 0.46 |
| ▸ | LMNA | P02545 | 5/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5311974 | 1.00 | MAPT (0.49) | MAPTKMT2ATDP1POLBATM | |
| SCHEMBL10708407 | 0.77 | MAPT (0.64) | MAPTKMT2ATDP1POLBATM | |
| SCHEMBL10708396 | 0.77 | MAPT (0.64) | MAPTKMT2ATDP1POLBATM | |
| SCHEMBL5306843 | 0.76 | KMT2A (0.51) | MAPTKMT2ATDP1POLBATM | |
| SCHEMBL5306846 | 0.76 | KMT2A (0.51) | MAPTKMT2ATDP1POLBATM | |
| SCHEMBL12313101 | 0.75 | KMT2A (0.46) | MAPTKMT2ATDP1POLBATM | |
| SCHEMBL11275822 | 0.70 | MAPT (0.55) | MAPTKMT2ATDP1POLBATM | |
| SCHEMBL5304083 | 0.70 | MEN1 (0.57) | MAPTKMT2ATDP1CCNT1CCNE2 | |
| SCHEMBL29769753 | 0.70 | MEN1 (0.57) | MAPTKMT2ATDP1CCNT1CCNE2 | |
| SCHEMBL5304078 | 0.70 | MEN1 (0.57) | MAPTKMT2ATDP1CCNT1CCNE2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007041677-A9 | SOFT TISSUE IMPLANTS AND DRUG COMBINATION COMPOSITIONS, AND USE THEREOF | COMBINATORX INC (US) | 2007-05-31 | — | — | WO | disclosed |
| WO-2007041677-A2 | SOFT TISSUE IMPLANTS AND DRUG COMBINATION COMPOSITIONS, AND USE THEREOF | COMBINATORX, INCORPORATED (US) | 2007-04-12 | — | — | WO | disclosed |