Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC3 | O15379 | 1/20 | 0.61 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.61 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.61 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.61 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.61 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.61 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.61 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.61 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.61 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.61 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.61 |
| ▸ | GRK2 | P25098 | 5/20 | 0.60 |
| ▸ | GRK1 | Q15835 | 2/20 | 0.60 |
| ▸ | MMP13 | P45452 | 3/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.56 |
| ▸ | GRK5 | P34947 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1500346 | 0.83 | GRK2 (0.60) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL28738323 | 0.83 | HDAC6 (0.61) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL13181831 | 0.83 | GRK2 (0.60) | GRK2GRK1MMP13SMN1; SMN2GRK5 | |
| SCHEMBL31742392 | 0.82 | HTT (0.58) | GRK2MMP13SMN1; SMN2 | |
| SCHEMBL14478795 | 0.82 | PDE5A (0.65) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL16210930 | 0.82 | SMN1; SMN2 (0.64) | HDAC1GRK2GRK1SMN1; SMN2GRK5 | |
| SCHEMBL29692294 | 0.82 | SMN1; SMN2 (0.64) | HDAC1GRK2GRK1SMN1; SMN2GRK5 | |
| SCHEMBL5427843 | 0.80 | GRK2 (0.57) | HDAC1GRK2GRK1MMP13SMN1; SMN2 | |
| SCHEMBL19911426 | 0.80 | CYP11B1 (0.66) | HDAC1HDAC8SMN1; SMN2LMNATNF | |
| SCHEMBL18034688 | 0.79 | GRK2 (0.56) | GRK2GRK1MMP13SMN1; SMN2GRK5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007053352-A2 | PYRROLOQUINOLINONE DERIVATIVES AS 5-HYDROXYTRYPTAMINE-6 LIGANDS | WYETH (US) | 2007-05-10 | — | — | WO | disclosed |
| US-20070099911-A1 | Pyrroloquinolinone derivatives as 5-hydroxytryptamine-6 ligands | WYETH (US) | 2007-05-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070099911-A1 | Pyrroloquinolinone derivatives as 5-hydroxytryptamine-6 ligands | HTR6, HTR5A, HTR2C | HDAC3 2042/4885HDAC4 2701/4885HDAC1 2479/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.