Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | ALDH2 | P05091 | 1/20 | 0.32 |
| ▸ | MAOA | P21397 | 1/20 | 0.32 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.32 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.32 |
| ▸ | RECQL | P46063 | 1/20 | 0.32 |
| ▸ | HTR1A | P08908 | 1/20 | 0.32 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13490827 | 0.94 | MAPK1 (0.41) | MAPK1ALDH1A1RECQL | |
| SCHEMBL1347193 | 0.89 | SLC6A4 (0.41) | MEN1KMT2AKDM4EALDH1A1SLC6A4 | |
| SCHEMBL29002957 | 0.87 | KDM4E (0.36) | MAPK1MEN1KMT2AKDM4ECYP1A2 | |
| SCHEMBL18860591 | 0.87 | MAPT (0.43) | MEN1KMT2AALDH2SLC6A4HTR1A | |
| SCHEMBL2809880 | 0.85 | PDE4A (0.39) | SLC6A4HTR1A | |
| SCHEMBL89284 | 0.85 | ALDH1A1 (0.39) | MAPK1MEN1KMT2ACYP1A2CYP2D6 | |
| SCHEMBL31214329 | 0.81 | KDM4E (0.50) | MAPK1KDM4ECYP1A2CYP2D6CYP2C19 | |
| SCHEMBL2062788 | 0.81 | KDM4E (0.50) | MAPK1KDM4ECYP1A2CYP2D6CYP2C19 | |
| SCHEMBL14646378 | 0.81 | LTA4H (0.38) | MAPK1MEN1KMT2ACYP1A2CYP2C19 | |
| SCHEMBL8264810 | 0.80 | MEN1 (0.43) | MAPK1MEN1KMT2AKDM4ECYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007044796-A2 | PYRIDAZINONE COMPOUNDS AS CALCILYTICS | NPS PHARMACEUTICALS, INC. (US) | 2007-04-19 | — | — | WO | disclosed |
| WO-2007044796-A2 | PYRIDAZINONE COMPOUNDS AS CALCILYTICS | NPS PHARMACEUTICALS, INC. (US) | 2007-04-19 | — | — | WO | disclosed |