Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 4/20 | 0.46 |
| ▸ | USP30 | Q70CQ3 | 8/20 | 0.44 |
| ▸ | JAK2 | O60674 | 1/20 | 0.42 |
| ▸ | JAK1 | P23458 | 1/20 | 0.42 |
| ▸ | PRKCG | P05129 | 1/20 | 0.42 |
| ▸ | PRKCB | P05771 | 1/20 | 0.42 |
| ▸ | PRKCA | P17252 | 1/20 | 0.42 |
| ▸ | PRKCH | P24723 | 1/20 | 0.42 |
| ▸ | PRKCE | Q02156 | 1/20 | 0.42 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.40 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.40 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.40 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.40 |
| ▸ | STS | P08842 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27616629 | 1.00 | GPR119 (0.46) | GPR119USP30JAK2JAK1PRKCG | |
| SCHEMBL4985438 | 0.88 | GPR119 (0.43) | GPR119USP30JAK2JAK1KDM4E | |
| SCHEMBL4989406 | 0.87 | GPR119 (0.42) | GPR119USP30JAK2JAK1KDM4E | |
| SCHEMBL5253699 | 0.84 | MAPT (0.46) | GPR119USP30JAK2JAK1KDM4E | |
| SCHEMBL3159082 | 0.83 | GPR119 (0.52) | GPR119PRKCGPRKCBPRKCAPRKCH | |
| SCHEMBL4993042 | 0.81 | SMN1; SMN2 (0.38) | GPR119USP30JAK2JAK1KDM4E | |
| SCHEMBL4993039 | 0.81 | GPR119 (0.38) | GPR119USP30JAK2JAK1PRKCG | |
| SCHEMBL25176769 | 0.81 | NAMPT (0.44) | GPR119USP30PRKCGPRKCBPRKCA | |
| SCHEMBL30958420 | 0.77 | GPR119 (0.43) | GPR119PRKCGPRKCBPRKCAPRKCH | |
| SCHEMBL30958418 | 0.77 | GPR119 (0.43) | GPR119PRKCGPRKCBPRKCAPRKCH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1487822-B1 | PYRROLE-2,5-DIONE DERIVATIVES AND THEIR USE AS GSK-3 INHIBITORS | LILLY CO ELI (US) | 2007-08-01 | — | — | EP | disclosed |
| CN-1639152-A | Pyrrole-2, 5-dione derivatives and their use as GSK-3 inhibitors | LILLY CO ELI (US) | 2005-07-13 | — | — | CN | disclosed |