Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 5/20 | 0.52 |
| ▸ | PRKCG | P05129 | 1/20 | 0.52 |
| ▸ | PRKCB | P05771 | 1/20 | 0.52 |
| ▸ | PRKCA | P17252 | 1/20 | 0.52 |
| ▸ | PRKCH | P24723 | 1/20 | 0.52 |
| ▸ | PRKCE | Q02156 | 1/20 | 0.52 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.52 |
| ▸ | DRD2 | P14416 | 1/20 | 0.51 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.51 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.48 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.48 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.48 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.48 |
| ▸ | HCAR1 | Q9BXC0 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | OGFRL1 | Q5TC84 | 1/20 | 0.46 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.46 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.46 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25176769 | 0.87 | NAMPT (0.44) | GPR119PRKCGPRKCBPRKCAPRKCH | |
| SCHEMBL5255201 | 0.84 | GPR119 (0.51) | GPR119PRKCGPRKCBPRKCAPRKCH | |
| SCHEMBL5254890 | 0.84 | GPR119 (0.51) | GPR119PRKCGPRKCBPRKCAPRKCH | |
| SCHEMBL3145435 | 0.84 | DRD2 (0.59) | DRD2SLC6A4OPRM1OPRD1OPRK1 | |
| SCHEMBL4990941 | 0.83 | STS (0.47) | GPR119HCAR1KDM4EMAPTTHRB | |
| SCHEMBL5253861 | 0.83 | STS (0.47) | GPR119HCAR1KDM4EMAPTTHRB | |
| SCHEMBL4898807 | 0.83 | USP30 (0.50) | GPR119PRKCGPRKCBPRKCAPRKCH | |
| SCHEMBL25339026 | 0.83 | USP30 (0.52) | GPR119PRKCGPRKCBPRKCAPRKCH | |
| SCHEMBL12459067 | 0.83 | NR1H2 (0.47) | GPR119PRKCGPRKCBPRKCAPRKCH | |
| SCHEMBL5312420 | 0.83 | GPR119 (0.46) | GPR119PRKCGPRKCBPRKCAPRKCH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240239794-A1 | PKC-Theta Modulators | EXSCIENTIA AI LIMITED (GB) | 2024-07-18 | — | — | US | disclosed |
| CN-117295738-A | PKC-theta modulators | 爱智药人工智能有限公司 | 2023-12-26 | — | — | CN | disclosed |
| US-20210246115-A1 | ANTI-INFECTIVE HETEROCYCLIC COMPOUNDS AND USES THEREOF | BIOIMICS AB (SE) | 2021-08-12 | — | — | US | disclosed |
| EP-3710426-A1 | ANTI-INFECTIVE HETEROCYCLIC COMPOUNDS AND USES THEREOF | Bioimics AB (SE) | 2020-09-23 | — | — | EP | disclosed |
| CN-111566085-A | Anti-infective heterocyclic compounds and uses thereof | 百欧伊米克思有限公司 | 2020-08-21 | — | — | CN | disclosed |
| CN-105308024-B | The nitrogenous heteroaromatic amide compound of two ring types | 安斯泰来制药株式会社 | 2017-10-27 | — | — | CN | disclosed |
| EP-1449529-B1 | Protein Kinase C Inhibitors | LILLY CO ELI (US) | 2010-01-27 | — | — | EP | disclosed |
| EP-0817627-B1 | PROTEIN KINASE C INHIBITORS | LILLY CO ELI (US) | 2005-03-09 | — | — | EP | disclosed |
| EP-1449529-A1 | Protein Kinase C Inhibitors | ELI LILLY AND COMPANY (US) | 2004-08-25 | — | — | EP | disclosed |
| EP-0817627-A1 | PROTEIN KINASE C INHIBITORS | ELI LILLY AND COMPANY (US) | 1998-01-14 | — | — | EP | disclosed |
| US-5672618-A | TREATING DIABETIC COMPLICATIONS | ELI LILLY AND COMPANY (US) | 1997-09-30 | — | — | US | disclosed |
| US-5668152-A | BIS/INDOLE/-SUBSTITUTED MALEIMIDES, ANTIDIABETIC AGENTS | ELI LILLY AND COMPANY (US) | 1997-09-16 | — | — | US | disclosed |
| US-5661173-A | ADMINISTERING AN ENZYME INHIBITOR TREATING DIABETES | ELI LILLY AND COMPANY (US) | 1997-08-26 | — | — | US | disclosed |
| US-5545636-A | TREATING DIABETES MELLITUS | ELI LILLY AND COMPANY (US) | 1996-08-13 | — | — | US | disclosed |
| WO-1995017182-A1 | PROTEIN KINASE C INHIBITORS | ELI LILLY AND COMPANY (US) | 1995-06-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240239794-A1 | PKC-Theta Modulators | PRKCQ, PRKCH, PRKCZ | GPR119 362/4885PRKCG 7/4885PRKCB 6/4885 |
| US-20210246115-A1 | ANTI-INFECTIVE HETEROCYCLIC COMPOUNDS AND USES THEREOF | FDPS, FPR1, F12 | GPR119 4399/4885PRKCG 4528/4885PRKCB 4762/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.