Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | UTS2R | Q9UKP6 | 10/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.50 |
| ▸ | ROCK1 | Q13464 | 5/20 | 0.49 |
| ▸ | ROCK2 | O75116 | 4/20 | 0.49 |
| ▸ | RPS6KA5 | O75582 | 3/20 | 0.49 |
| ▸ | AKT1 | P31749 | 3/20 | 0.49 |
| ▸ | GSK3B | P49841 | 3/20 | 0.49 |
| ▸ | NEK4 | P51957 | 3/20 | 0.49 |
| ▸ | PRKCD | Q05655 | 3/20 | 0.49 |
| ▸ | PRKG2 | Q13237 | 3/20 | 0.49 |
| ▸ | PRKG1 | Q13976 | 3/20 | 0.49 |
| ▸ | PKN2 | Q16513 | 3/20 | 0.49 |
| ▸ | CLK4 | Q9HAZ1 | 3/20 | 0.49 |
| ▸ | MAPK13 | O15264 | 2/20 | 0.49 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.49 |
| ▸ | PRKCG | P05129 | 2/20 | 0.49 |
| ▸ | CDK1 | P06493 | 2/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7994713 | 0.93 | MEN1 (0.58) | MEN1POLBKMT2AUTS2RCYP3A4 | |
| SCHEMBL5926424 | 0.91 | UTS2R (0.49) | MEN1POLBKMT2AUTS2RCYP3A4 | |
| SCHEMBL5927020 | 0.90 | THRB (0.49) | MEN1POLBKMT2AUTS2RCYP3A4 | |
| SCHEMBL5926341 | 0.90 | THRB (0.49) | MEN1POLBKMT2AUTS2RCYP3A4 | |
| SCHEMBL3991800 | 0.88 | CTSA (0.56) | UTS2RCYP3A4ROCK1ROCK2RPS6KA5 | |
| SCHEMBL5926607 | 0.87 | CYP3A4 (0.47) | CYP3A4ALDH1A1 | |
| SCHEMBL5926414 | 0.86 | TACR3 (0.50) | MEN1POLBKMT2AROCK1ROCK2 | |
| SCHEMBL5926555 | 0.84 | MAPK14 (0.52) | UTS2RCYP3A4ROCK1ROCK2RPS6KA5 | |
| SCHEMBL4824256 | 0.82 | TRPM8 (0.45) | MEN1KMT2AUTS2RMAP4K4MINK1 | |
| SCHEMBL5926625 | 0.82 | MAPK14 (0.55) | MEN1KMT2AUTS2RROCK1ROCK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007044574-A2 | PHARMACEUTICAL COMPOSITIONS, METHODS OF PREPARATION THEREOF, AND METHODS OF TREATMENT | TRANSTECH PHARMA, INC. (US) | 2007-04-19 | — | — | WO | claimed |
| US-20070082952-A1 | Pharmaceutical compositions, methods of preparation thereof, and methods of treatment | TRANSTECH PHARMA, INC. | 2007-04-12 | — | — | US | claimed |
| US-20070185204-A1 | Crystalline forms of 3-biphenyl-4-yl-(2S)-[(4'-trifluoromethyl-biphenyl-4-carbonyl)-amino]-propionic acid, and methods of use | TRANSTECH PHARMA, INC. | 2007-08-09 | — | — | US | disclosed |
| WO-2007087148-A1 | CRYSTALLINE FORMS OF 3-BIPHENYL-4-YL-(2S)-[(4'-TRIFLUOROMETHYL-BIPHENYL-4-CARBONYL)-AMINO]-PROPIONIC ACID, AND METHODS OF USE | TRANSTECH PHARMA, INC. (US) | 2007-08-02 | — | — | WO | disclosed |
| WO-2007044574-A2 | PHARMACEUTICAL COMPOSITIONS, METHODS OF PREPARATION THEREOF, AND METHODS OF TREATMENT | TRANSTECH PHARMA, INC. (US) | 2007-04-19 | — | — | WO | disclosed |
| US-20070082952-A1 | Pharmaceutical compositions, methods of preparation thereof, and methods of treatment | TRANSTECH PHARMA, INC. | 2007-04-12 | — | — | US | disclosed |