Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.51 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.47 |
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.47 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.47 |
| ▸ | CXCR2 | P25025 | 1/20 | 0.47 |
| ▸ | PIM1 | P11309 | 1/20 | 0.45 |
| ▸ | DDX3X | O00571 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | GFER | P55789 | 1/20 | 0.42 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.42 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2927614 | 0.84 | AKR1C3 (0.49) | KMT2AMEN1AKR1C3CXCR2PIM1 | |
| SCHEMBL1201581 | 0.80 | KMT2A (0.42) | MAPTKMT2AMEN1KDM4EL3MBTL1 | |
| SCHEMBL697780 | 0.78 | KDM4E (0.54) | MAPTKMT2AMEN1KDM4EL3MBTL1 | |
| SCHEMBL12109510 | 0.77 | KDM4E (0.46) | MAPTKMT2AMEN1KDM4EPIM1 | |
| SCHEMBL10212480 | 0.76 | KDM4E (0.55) | MAPTKMT2AMEN1KDM4EL3MBTL1 | |
| SCHEMBL31391099 | 0.76 | KDM4E (0.48) | MAPTKMT2AMEN1KDM4EPIM1 | |
| SCHEMBL7005938 | 0.76 | KDM4E (0.45) | MAPTKMT2AMEN1KDM4EPIM1 | |
| SCHEMBL1202057 | 0.76 | ALDH1A1 (0.47) | MAPTKMT2AMEN1KDM4EPIM1 | |
| SCHEMBL18410602 | 0.76 | PIM1 (0.49) | MAPTKMT2AMEN1KDM4EAKR1C3 | |
| SCHEMBL18236212 | 0.76 | PIM1 (0.49) | MAPTKMT2AMEN1KDM4EAKR1C3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1863771-A2 | BENZAZOLE DERIVATIVES, COMPOSITIONS, AND METHODS OF USE AS B-SECRETASE INHIBITORS | Transtech Pharma, Inc. (US) | 2007-12-12 | — | — | EP | disclosed |
| WO-2006099379-A2 | BENZAZOLE DERIVATIVES, COMPOSITIONS, AND METHODS OF USE AS B-SECRETASE INHIBITORS | TRANSTECH PHARMA, INC. (US) | 2006-09-21 | — | — | WO | disclosed |