Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 15/20 | 0.72 |
| ▸ | CA2 | P00918 | 10/20 | 0.72 |
| ▸ | CA9 | Q16790 | 9/20 | 0.72 |
| ▸ | CA12 | O43570 | 8/20 | 0.72 |
| ▸ | PTGS1 | P23219 | 8/20 | 0.72 |
| ▸ | CA1 | P00915 | 8/20 | 0.69 |
| ▸ | CA7 | P43166 | 2/20 | 0.69 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5312634 | 1.00 | PTGS2 (0.72) | PTGS2CA2CA9CA12PTGS1 | |
| SCHEMBL5314090 | 0.89 | PTGS2 (0.69) | PTGS2CA2CA9CA12PTGS1 | |
| SCHEMBL5314093 | 0.89 | PTGS2 (0.69) | PTGS2CA2CA9CA12PTGS1 | |
| SCHEMBL18719792 | 0.87 | PTGS2 (0.55) | PTGS2CA2CA9CA12PTGS1 | |
| SCHEMBL12416627 | 0.85 | KMT2A (0.57) | — | |
| SCHEMBL19460778 | 0.85 | KMT2A (0.57) | — | |
| SCHEMBL5311504 | 0.84 | PTGS2 (1.00) | PTGS2CA2CA9CA12PTGS1 | |
| SCHEMBL1517619 | 0.84 | PTGS2 (1.00) | PTGS2CA2CA9CA12PTGS1 | |
| SCHEMBL5311501 | 0.84 | PTGS2 (1.00) | PTGS2CA2CA9CA12PTGS1 | |
| SCHEMBL5308961 | 0.84 | PTGS2 (1.00) | PTGS2CA2CA9CA12PTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10471028-B2 | Small molecule efflux pump inhibitors | UNIVERSITY OF ROCHESTER (US) | 2019-11-12 | — | — | US | disclosed |
| US-20170100414-A1 | SMALL MOLECULE EFFLUX PUMP INHIBITORS | UNIVERSITY OF ROCHESTER (US) | 2017-04-13 | — | — | US | disclosed |
| US-20170100414-A1 | SMALL MOLECULE EFFLUX PUMP INHIBITORS | UNIVERSITY OF ROCHESTER (US) | 2017-04-13 | — | — | US | disclosed |
| EP-0799823-B1 | 1,2-Diphenylpyrrole derivatives, their preparation and their therapeutic uses | DAIICHI SANKYO CO LTD (JP) | 2007-10-31 | — | — | EP | disclosed |
| US-RE39420-E1 | 1,2-Diphenylpyrrole derivatives, their preparation and their therapeutic uses | SANKYO COMPANY, LIMITED (JP) | 2006-12-05 | — | — | US | disclosed |
| US-5908858-A | OSTEOPOROSIS; LEUKOTRIENE INHIBITOR | SANKYO COMPANY, LIMITED (JP) | 1999-06-01 | — | — | US | disclosed |
| EP-0799823-A1 | 1,2-Diphenylpyrrole derivatives, their preparation and their therapeutic uses | SANKYO COMPANY LIMITED (JP) | 1997-10-08 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10471028-B2 | Small molecule efflux pump inhibitors | ABCB11, ABCB1, ABCC1 | PTGS2 469/4885CA2 2754/4885CA9 3610/4885 |
| US-20170100414-A1 | SMALL MOLECULE EFFLUX PUMP INHIBITORS | ABCB11, ABCB1, ABCC1 | PTGS2 469/4885CA2 2754/4885CA9 3610/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.