Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC3 | O15379 | 6/20 | 0.62 |
| ▸ | HDAC4 | P56524 | 6/20 | 0.62 |
| ▸ | HDAC1 | Q13547 | 6/20 | 0.62 |
| ▸ | HDAC7 | Q8WUI4 | 6/20 | 0.62 |
| ▸ | HDAC2 | Q92769 | 6/20 | 0.62 |
| ▸ | HDAC10 | Q969S8 | 6/20 | 0.62 |
| ▸ | HDAC11 | Q96DB2 | 6/20 | 0.62 |
| ▸ | HDAC8 | Q9BY41 | 6/20 | 0.62 |
| ▸ | HDAC6 | Q9UBN7 | 6/20 | 0.62 |
| ▸ | HDAC9 | Q9UKV0 | 6/20 | 0.62 |
| ▸ | HDAC5 | Q9UQL6 | 6/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.61 |
| ▸ | GAA | P10253 | 6/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.61 |
| ▸ | HPGD | P15428 | 6/20 | 0.60 |
| ▸ | CASP1 | P29466 | 5/20 | 0.60 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.60 |
| ▸ | GLA | P06280 | 6/20 | 0.59 |
| ▸ | CASP7 | P55210 | 2/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL732843 | 0.90 | HDAC3 (0.64) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL14494711 | 0.88 | ALDH1A1 (0.65) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL14494591 | 0.86 | ALDH1A1 (0.66) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL4518944 | 0.85 | HDAC3 (0.56) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL309010 | 0.84 | KMT2A (0.58) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL11107382 | 0.83 | KDM4E (0.66) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL8914017 | 0.82 | EPHX2 (0.63) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL5316847 | 0.82 | HDAC3 (0.54) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL2127507 | 0.82 | HDAC3 (0.79) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL2127498 | 0.82 | HDAC3 (0.79) | HDAC3HDAC4HDAC1HDAC7HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007063385-A2 | SPIROCYCLIC AMINE HISTAMINE-3 RECEPTOR ANTAGONISTS | PFIZER PRODUCTS INC. (US) | 2007-06-07 | — | — | WO | disclosed |
| WO-2007063385-A2 | SPIROCYCLIC AMINE HISTAMINE-3 RECEPTOR ANTAGONISTS | PFIZER PRODUCTS INC. (US) | 2007-06-07 | — | — | WO | disclosed |