Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LCK | P06239 | 10/20 | 0.40 |
| ▸ | KDR | P35968 | 4/20 | 0.38 |
| ▸ | BRAF | P15056 | 3/20 | 0.38 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.38 |
| ▸ | IKBKB | O14920 | 1/20 | 0.35 |
| ▸ | RAF1 | P04049 | 1/20 | 0.35 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.35 |
| ▸ | CDK1 | P06493 | 1/20 | 0.35 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.35 |
| ▸ | KIT | P10721 | 1/20 | 0.35 |
| ▸ | SRC | P12931 | 1/20 | 0.35 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.35 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.35 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.35 |
| ▸ | TEK | Q02763 | 1/20 | 0.35 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.35 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.35 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.33 |
| ▸ | CSNK1D | P48730 | 2/20 | 0.32 |
| ▸ | RXRA | P19793 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5315703 | 0.94 | LCK (0.40) | LCKKDRBRAFIRAK4IKBKB | |
| SCHEMBL5311328 | 0.88 | LCK (0.43) | LCKKDR | |
| SCHEMBL5310236 | 0.87 | LCK (0.50) | LCKKDR | |
| SCHEMBL5314682 | 0.87 | LCK (0.43) | LCKKDRBRAFIRAK4IKBKB | |
| SCHEMBL5311465 | 0.87 | KDR (0.46) | LCKKDR | |
| SCHEMBL5312683 | 0.85 | LCK (0.39) | LCKKDRBRAFIRAK4IKBKB | |
| SCHEMBL5315267 | 0.83 | LCK (0.40) | LCKKDRBRAFIRAK4IKBKB | |
| SCHEMBL5312793 | 0.81 | LCK (0.38) | LCKBRAFIRAK4RAF1ROCK2 | |
| SCHEMBL5314751 | 0.79 | LCK (0.50) | LCKKDRBRAFIRAK4IKBKB | |
| SCHEMBL5310105 | 0.78 | KDR (0.46) | LCKKDRBRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007058482-A1 | NOVEL INHIBITORS OF PROTEIN KINASE | LG LIFE SCIENCES, LTD. (KR) | 2007-05-24 | — | — | WO | disclosed |