Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IKBKB | O14920 | 11/20 | 0.46 |
| ▸ | CHUK | O15111 | 10/20 | 0.46 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | LCK | P06239 | 1/20 | 0.37 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.37 |
| ▸ | NQO2 | P16083 | 1/20 | 0.36 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.35 |
| ▸ | CCND1 | P24385 | 1/20 | 0.35 |
| ▸ | CCNC | P24863 | 1/20 | 0.35 |
| ▸ | CDK8 | P49336 | 1/20 | 0.35 |
| ▸ | CDK7 | P50613 | 1/20 | 0.35 |
| ▸ | CDK9 | P50750 | 1/20 | 0.35 |
| ▸ | CCNH | P51946 | 1/20 | 0.35 |
| ▸ | MNAT1 | P51948 | 1/20 | 0.35 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.35 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.35 |
| ▸ | BTK | Q06187 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1684153 | 0.74 | IKBKB (0.39) | IKBKBCHUKPDPK1 | |
| SCHEMBL31205138 | 0.70 | RIPK1 (0.48) | IKBKBCHUKPDPK1LMNALCK | |
| SCHEMBL6246419 | 0.70 | LMNA (0.51) | LMNA | |
| SCHEMBL4172394 | 0.70 | NQO2 (0.40) | IKBKBCHUKPDPK1LMNALCK | |
| SCHEMBL1207795 | 0.69 | HDAC6 (0.48) | IKBKBCHUKLCKRIPK1CCNT1 | |
| SCHEMBL29754771 | 0.68 | LCK (0.46) | LMNALCK | |
| SCHEMBL30540478 | 0.68 | GRM2 (0.39) | IKBKBCHUKPDPK1LMNA | |
| Hydrochloric Acid SCHEMBL3831639 | 0.68 | HDAC6 (0.47) | IKBKBCHUKLCKRIPK1CCNT1 | |
| SCHEMBL20987263 | 0.67 | IKBKB (0.46) | IKBKBCHUKPDPK1LCKRIPK1 | |
| SCHEMBL29898213 | 0.67 | IKBKB (0.62) | IKBKBCHUKPDPK1KEAP1BTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1802619-A1 | INHIBITORS OF THE HIV INTEGRASE ENZYME | Pfizer, Inc. (US) | 2007-07-04 | — | — | EP | disclosed |
| WO-2006027694-A1 | INHIBITORS OF THE HIV INTEGRASE ENZYME | PFIZER INC. (US) | 2006-03-16 | — | — | WO | disclosed |