Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 | Q14145 | 3/20 | 0.50 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | NR3C1 | P04150 | 3/20 | 0.44 |
| ▸ | GLO1 | Q04760 | 2/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | PGR | P06401 | 2/20 | 0.44 |
| ▸ | NR3C2 | P08235 | 2/20 | 0.44 |
| ▸ | AR | P10275 | 2/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | JAK2 | O60674 | 1/20 | 0.41 |
| ▸ | JAK1 | P23458 | 1/20 | 0.41 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3789124 | 0.86 | KEAP1 (0.59) | KEAP1NFE2L2L3MBTL1NR3C1GLO1 | |
| SCHEMBL11238658 | 0.81 | KEAP1 (0.53) | KEAP1NFE2L2L3MBTL1NR3C1GLO1 | |
| SCHEMBL4649314 | 0.80 | KEAP1 (0.55) | KEAP1NFE2L2L3MBTL1NR3C1GLO1 | |
| SCHEMBL4090066 | 0.78 | KEAP1 (0.50) | KEAP1NFE2L2L3MBTL1NR3C1GLO1 | |
| SCHEMBL21931409 | 0.78 | KEAP1 (0.50) | KEAP1NFE2L2L3MBTL1NR3C1GLO1 | |
| SCHEMBL13690065 | 0.76 | KMT2A (0.46) | KEAP1NFE2L2L3MBTL1NR3C1GLO1 | |
| SCHEMBL1850852 | 0.74 | PTGS1 (0.49) | KEAP1NFE2L2L3MBTL1NR3C1GLO1 | |
| SCHEMBL3529403 | 0.74 | KMT2A (0.55) | KEAP1NFE2L2HTTPGRAR | |
| SCHEMBL13602477 | 0.74 | ALDH1A1 (0.54) | KEAP1NFE2L2NR3C1HTTKDM4E | |
| SCHEMBL2068498 | 0.73 | KEAP1 (0.65) | KEAP1NFE2L2L3MBTL1NR3C1GLO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007039125-A2 | AN OPTICALLY ACTIVE THYROID RECEPTOR AGONIST AND OPTICALLY ACTIVE KEY INTERMEDIATES IN ITS PRODUCTION | KARO BIO AB (SE) | 2007-04-12 | — | — | WO | claimed |
| WO-2007039125-A2 | AN OPTICALLY ACTIVE THYROID RECEPTOR AGONIST AND OPTICALLY ACTIVE KEY INTERMEDIATES IN ITS PRODUCTION | KARO BIO AB (SE) | 2007-04-12 | — | — | WO | disclosed |