Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HNF4A | P41235 | 4/20 | 0.53 |
| ▸ | ACMSD | Q8TDX5 | 4/20 | 0.53 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.53 |
| ▸ | DHFR | P00374 | 1/20 | 0.53 |
| ▸ | CA1 | P00915 | 3/20 | 0.50 |
| ▸ | CA2 | P00918 | 3/20 | 0.50 |
| ▸ | CA12 | O43570 | 2/20 | 0.50 |
| ▸ | CA7 | P43166 | 2/20 | 0.50 |
| ▸ | CA9 | Q16790 | 2/20 | 0.50 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.50 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.50 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.50 |
| ▸ | PTPN1 | P18031 | 3/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | HPGD | P15428 | 3/20 | 0.48 |
| ▸ | HMGB1 | P09429 | 1/20 | 0.48 |
| ▸ | CA4 | P22748 | 1/20 | 0.48 |
| ▸ | CA6 | P23280 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1048685 | 0.94 | CA1 (0.55) | HNF4AACMSDMCL1DHFRCA1 | |
| SCHEMBL7711866 | 0.89 | MCL1 (0.58) | HNF4AACMSDMCL1DHFRCA1 | |
| SCHEMBL10728975 | 0.87 | MEN1 (0.46) | HNF4AACMSDMCL1DHFRCA1 | |
| SCHEMBL6539439 | 0.86 | CA12 (0.52) | HNF4AACMSDMCL1DHFRCA1 | |
| SCHEMBL7706125 | 0.85 | ACMSD (0.49) | HNF4AACMSDMCL1DHFRCA1 | |
| SCHEMBL7709289 | 0.85 | ACMSD (0.49) | HNF4AACMSDMCL1DHFRCA1 | |
| SCHEMBL15882918 | 0.82 | CA1 (0.71) | HNF4AACMSDMCL1DHFRCA1 | |
| SCHEMBL489842 | 0.81 | TDP1 (0.59) | HNF4AACMSDMCL1DHFRCA1 | |
| SCHEMBL29417548 | 0.81 | TDP1 (0.59) | HNF4AACMSDMCL1DHFRCA1 | |
| SCHEMBL7895174 | 0.81 | ACMSD (0.53) | HNF4AACMSDMCL1DHFRCA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007047815-A2 | DIAGNOSIS OF TRANSMISSIBLE SPONGIFORM ENCEPHALOPATHY | THE BRIGHAM AND WOMEN'S HOSPITAL, INC. (US) | 2007-04-26 | — | — | WO | claimed |
| CN-110208540-B | Methods and compositions for the detection and treatment of preeclampsia | 耶鲁大学 | 2024-02-09 | — | — | CN | disclosed |
| CN-110187119-B | Methods and compositions for the detection and treatment of preeclampsia | 耶鲁大学 | 2022-07-29 | — | — | CN | disclosed |
| CN-110187120-B | Methods and compositions for the detection and treatment of preeclampsia | 耶鲁大学 | 2022-07-01 | — | — | CN | disclosed |
| CN-110187121-B | Methods and compositions for the detection and treatment of preeclampsia | 耶鲁大学 | 2022-07-01 | — | — | CN | disclosed |
| CN-104777307-B | The method and composition of pre-eclampsia detection and treatment | 耶鲁大学 | 2019-10-18 | — | — | CN | disclosed |
| CN-105044347-A | Methods and compositions for the detection and treatment of preeclampsia | UNIV YALE | 2015-11-11 | — | — | CN | disclosed |
| CN-105021821-A | ETHODS AND COMPOSITIONS FOR THE DETECTION AND TREATMENT OF PREECLAMPSIA | UNIV YALE | 2015-11-04 | — | — | CN | disclosed |
| CN-104777307-A | Methods and compositions for the detection and treatment of preeclampsia | UNIV YALE | 2015-07-15 | — | — | CN | disclosed |
| CN-104777308-A | Methods and compositions for the detection and treatment of preeclampsia | UNIV YALE | 2015-07-15 | — | — | CN | disclosed |
| CN-102483418-B | Methods and compositions for the detection and treatment of preeclampsia | UNIV YALE | 2015-01-07 | — | — | CN | disclosed |
| CN-102483418-A | Methods and compositions for the detection and treatment of preeclampsia | UNIV YALE | 2012-05-30 | — | — | CN | disclosed |
| WO-1999024394-A9 | COMPOUNDS FOR THE ANTEMORTEM DIAGNOSIS OF ALZHEIMER'S DISEASE AND IN VIVO IMAGING AND PREVENTION OF AMYLOID DEPOSITION | UNIV PITTSBURGH (US) | 2001-05-31 | — | — | WO | disclosed |
| US-6168776-B1 | Alkyl, alkenyl and alkynyl Chrysamine G derivatives for the antemortem diagnosis of Alzheimer's disease and in vivo imaging and prevention of amyloid deposition | UNIVERSITY OF PITTSBURGH | 2001-01-02 | — | — | US | disclosed |
| EP-1028941-A2 | COMPOUNDS FOR THE ANTEMORTEM DIAGNOSIS OF ALZHEIMER'S DISEASE AND IN VIVO IMAGING AND PREVENTION OF AMYLOID DEPOSITION | UNIVERSITY OF PITTSBURGH (US) | 2000-08-23 | — | — | EP | disclosed |
| WO-1999024394-A2 | COMPOUNDS FOR THE ANTEMORTEM DIAGNOSIS OF ALZHEIMER'S DISEASE AND IN VIVO IMAGING AND PREVENTION OF AMYLOID DEPOSITION | UNIVERSITY OF PITTSBURGH (US) | 1999-05-20 | — | — | WO | disclosed |