Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 4/20 | 0.45 |
| ▸ | GSR | P00390 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | BLM | P54132 | 1/20 | 0.39 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | PTPN1 | P18031 | 3/20 | 0.37 |
| ▸ | PTPN2 | P17706 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4973045 | 0.73 | PTGS2 (0.41) | PTGS2GSRKMT2AMEN1LMNA | |
| SCHEMBL27442348 | 0.73 | PTGS2 (0.41) | PTGS2GSRKMT2AMEN1LMNA | |
| SCHEMBL1797330 | 0.71 | PTGS2 (0.67) | PTGS2KMT2AMEN1LMNATDP1 | |
| SCHEMBL4975519 | 0.70 | PTGS2 (0.39) | PTGS2GSRKMT2AMEN1LMNA | |
| SCHEMBL27813684 | 0.69 | PTGS2 (0.47) | PTGS2KMT2AMEN1LMNATDP1 | |
| SCHEMBL1092219 | 0.69 | CYP19A1 (0.53) | PTGS2KMT2AMEN1LMNATDP1 | |
| SCHEMBL3658890 | 0.69 | HSP90AA1 (0.54) | PTGS2KMT2AMEN1LMNATDP1 | |
| SCHEMBL5425872 | 0.69 | PTGS2 (0.47) | PTGS2KMT2AMEN1LMNATDP1 | |
| SCHEMBL27217198 | 0.69 | PTGS2 (0.44) | PTGS2KMT2AMEN1LMNATDP1 | |
| SCHEMBL27514872 | 0.69 | PTGS2 (0.44) | PTGS2KMT2AMEN1LMNATDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1765795-A2 | ALKYNYL DERIVATIVES AS MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS | Addex Pharmaceuticals SA (CH) | 2007-03-28 | — | — | EP | disclosed |
| WO-2005123703-A2 | ALKYNYL DERIVATIVES AS MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS | ADDEX PHARMACEUTICALS SA (CH) | 2005-12-29 | — | — | WO | disclosed |