Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TTR | P02766 | 6/20 | 0.47 |
| ▸ | GPR35 | Q9HC97 | 7/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.42 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11313392 | 0.84 | GPR35 (0.56) | TTRGPR35ALDH1A1HPGDALOX15 | |
| SCHEMBL3286500 | 0.82 | GPR35 (0.61) | TTRGPR35ALDH1A1HPGDALOX15 | |
| SCHEMBL10886742 | 0.82 | GPR35 (0.59) | TTRGPR35ALDH1A1HPGDALOX15 | |
| SCHEMBL10884469 | 0.82 | CYP3A4 (0.58) | TTRGPR35ALDH1A1HPGDALOX15 | |
| SCHEMBL29190122 | 0.81 | GPR35 (0.43) | TTRGPR35ALDH1A1HPGDALOX15 | |
| SCHEMBL27001787 | 0.81 | ERN1 (0.54) | TTRGPR35ALDH1A1HPGDALOX15 | |
| SCHEMBL11326702 | 0.81 | MAPT (0.49) | TTRGPR35ALDH1A1HPGDALOX15 | |
| SCHEMBL7027024 | 0.79 | GPR35 (0.42) | TTRGPR35ALDH1A1HPGDALOX15 | |
| SCHEMBL7021582 | 0.79 | GPR35 (0.42) | TTRGPR35ALDH1A1HPGDALOX15 | |
| SCHEMBL8902847 | 0.79 | ALDH1A1 (0.53) | ALDH1A1HPGDALOX15HIF1ATDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1765795-A2 | ALKYNYL DERIVATIVES AS MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS | Addex Pharmaceuticals SA (CH) | 2007-03-28 | — | — | EP | disclosed |
| WO-2005123703-A2 | ALKYNYL DERIVATIVES AS MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS | ADDEX PHARMACEUTICALS SA (CH) | 2005-12-29 | — | — | WO | disclosed |