Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 8/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 1.00 |
| ▸ | HPGD | P15428 | 3/20 | 1.00 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.58 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.56 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.49 |
| ▸ | GLA | P06280 | 2/20 | 0.48 |
| ▸ | GAA | P10253 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.47 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.46 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.46 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 6/20 | 0.46 |
| ▸ | RAB9A | P51151 | 5/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL935169 | 0.80 | ALDH1A1 (0.67) | KDM4EALDH1A1HPGDCLK4KCNA5 | |
| SCHEMBL7113110 | 0.80 | KDM4E (0.67) | KDM4EALDH1A1HPGDKMT2ACLK4 | |
| SCHEMBL6843188 | 0.79 | ALDH1A1 (0.66) | KDM4EALDH1A1HPGDKMT2AGLA | |
| SCHEMBL16048953 | 0.79 | KDM4E (0.66) | KDM4EALDH1A1HPGDKMT2ACLK4 | |
| SCHEMBL30610433 | 0.79 | KDM4E (0.65) | KDM4EALDH1A1HPGDKMT2ACLK4 | |
| SCHEMBL12521001 | 0.79 | KDM4E (0.65) | KDM4EALDH1A1HPGDKMT2ACLK4 | |
| SCHEMBL1551352 | 0.79 | KDM4E (0.65) | KDM4EALDH1A1HPGDKMT2ACLK4 | |
| SCHEMBL27268728 | 0.79 | KDM4E (0.65) | KDM4EALDH1A1HPGDKMT2ACLK4 | |
| SCHEMBL5330253 | 0.79 | KDM4E (0.65) | KDM4EALDH1A1HPGDKMT2ACLK4 | |
| SCHEMBL27530672 | 0.78 | ALDH1A1 (0.64) | KDM4EALDH1A1HPGDKMT2ACLK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070148185-A1 | Novel therapeutic target for protozoal diseases | VIRGINIA POLYTECHNIC INSTITUTE AND STATE UNIVERSITY | 2007-06-28 | — | — | US | claimed |
| WO-2007047579-A2 | A NOVEL THERAPEUTIC TARGET FOR PROTOZOAL DISEASES | VIRGINIA TECH INTELLECTUAL PROPERTIES, INC. (US) | 2007-04-26 | — | — | WO | claimed |
| US-20070148185-A1 | Novel therapeutic target for protozoal diseases | VIRGINIA POLYTECHNIC INSTITUTE AND STATE UNIVERSITY | 2007-06-28 | — | — | US | disclosed |