Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES2 | O00748 | 1/20 | 0.50 |
| ▸ | RXRA | P19793 | 4/20 | 0.44 |
| ▸ | RXRB | P28702 | 4/20 | 0.44 |
| ▸ | RXRG | P48443 | 3/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | GPR35 | Q9HC97 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | P2RX1 | P51575 | 1/20 | 0.41 |
| ▸ | APP | P05067 | 1/20 | 0.40 |
| ▸ | TACR1 | P25103 | 4/20 | 0.40 |
| ▸ | AR | P10275 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14815251 | 0.84 | CES2 (0.52) | CES2MAPTALDH1A1LMNAP2RX1 | |
| SCHEMBL30434274 | 0.83 | CES2 (0.50) | CES2ALDH1A1LMNAAPP | |
| SCHEMBL4028192 | 0.80 | APP (0.53) | CES2RXRARXRBRXRGMAPT | |
| SCHEMBL531511 | 0.80 | CES2 (0.52) | CES2RXRARXRBRXRGMAPT | |
| Hydrochloric Acid SCHEMBL5756823 | 0.78 | APP (0.51) | CES2RXRARXRBRXRGMAPT | |
| SCHEMBL3941437 | 0.78 | CES2 (0.39) | CES2RXRARXRBRXRGMAPT | |
| SCHEMBL3941432 | 0.78 | CES2 (0.39) | CES2RXRARXRBRXRGMAPT | |
| SCHEMBL11844486 | 0.78 | KIF11 (0.52) | CES2RXRARXRBRXRGAPP | |
| SCHEMBL27667242 | 0.76 | TPMT (0.44) | RXRARXRBMAPTALDH1A1LMNA | |
| SCHEMBL30221940 | 0.75 | CES2 (0.47) | CES2RXRARXRBRXRGMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2415759-A1 | CETP inhibitors | Merck Sharp & Dohme Corporation (US) | 2012-02-08 | — | — | EP | disclosed |
| US-7652049-B2 | 1-benzyl-4-[4'-fluoro-5'-isopropyl-2'-methoxy-4-(trifluoromethyl)biphenyl-2-yl]imidazolidin-2-one; cholesteryl ester transfer protein inhibitor; raising HDL-cholesterol, reducing LDL-cholesterol; atherosclerosis; antiinflammatory agent; synergistic mixture with other active ingredients | MERCK & CO., INC. (US) | 2010-01-26 | — | — | US | disclosed |