Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IP6K1 | Q92551 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 3/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.45 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.45 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.45 |
| ▸ | DHFR | P00374 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7052975 | 0.81 | PIM1 (0.47) | IP6K1LMNASMN1; SMN2PIK3CDPIK3R1 | |
| SCHEMBL1873126 | 0.78 | ADRA2A (0.37) | SMN1; SMN2ALDH1A1KDM4EMAPTADRA2A | |
| SCHEMBL14876436 | 0.77 | KDM4E (0.62) | IP6K1LMNASMN1; SMN2DHFRALDH1A1 | |
| SCHEMBL5182572 | 0.75 | NR1H2 (0.50) | ALDH1A1TSHRCYP1A2CYP3A4CYP2D6 | |
| SCHEMBL1135398 | 0.75 | DHFR (0.47) | IP6K1LMNASMN1; SMN2PIK3CDPIK3R1 | |
| SCHEMBL28041767 | 0.75 | IP6K1 (0.44) | IP6K1DHFRNR1H2NR1H3KMT2A | |
| SCHEMBL2170597 | 0.75 | SLC6A2 (0.37) | ALDH1A1TSHRKDM4ECYP1A2CYP3A4 | |
| SCHEMBL20853609 | 0.75 | HTT (0.48) | IP6K1LMNASMN1; SMN2PIK3CDPIK3R1 | |
| SCHEMBL31162515 | 0.73 | POLB (0.41) | ALDH1A1KDM4EPOLBMAPT | |
| SCHEMBL31162481 | 0.73 | MAPT (0.40) | HIF1AALDH1A1TSHRKDM4ECYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007057775-A1 | SPIROPIPERIDINE DERIVATIVES | PFIZER LIMITED (GB) | 2007-05-24 | — | — | WO | disclosed |
| WO-2007057775-A1 | SPIROPIPERIDINE DERIVATIVES | PFIZER LIMITED (GB) | 2007-05-24 | — | — | WO | disclosed |