Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.64 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.62 |
| ▸ | PKM | P14618 | 1/20 | 0.62 |
| ▸ | HPGD | P15428 | 1/20 | 0.60 |
| ▸ | NPC1 | O15118 | 2/20 | 0.58 |
| ▸ | RAB9A | P51151 | 2/20 | 0.58 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.55 |
| ▸ | MEN1 | O00255 | 4/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.51 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11360445 | 0.84 | CTSL (0.64) | ALDH1A1SMN1; SMN2PKMHPGDNPC1 | |
| SCHEMBL16364129 | 0.84 | ALDH1A1 (0.62) | ALDH1A1SMN1; SMN2PKMHPGDNPC1 | |
| SCHEMBL11683297 | 0.81 | ALDH1A1 (0.68) | ALDH1A1SMN1; SMN2PKMHPGDNPC1 | |
| SCHEMBL11597081 | 0.80 | ALDH1A1 (0.57) | ALDH1A1SMN1; SMN2PKMHPGDNPC1 | |
| SCHEMBL4587893 | 0.79 | ALDH1A1 (0.70) | ALDH1A1SMN1; SMN2PKMHPGDNPC1 | |
| SCHEMBL23521348 | 0.79 | ALDH1A1 (0.60) | ALDH1A1SMN1; SMN2PKMHPGDNPC1 | |
| SCHEMBL7747888 | 0.79 | TMEM97 (0.48) | ALDH1A1SMN1; SMN2PKMHPGDNPC1 | |
| SCHEMBL13074753 | 0.79 | ALDH1A1 (0.64) | ALDH1A1SMN1; SMN2PKMHPGDNPC1 | |
| SCHEMBL6361865 | 0.79 | ALDH1A1 (0.74) | ALDH1A1SMN1; SMN2PKMHPGDNPC1 | |
| SCHEMBL10842770 | 0.78 | ALDH1A1 (0.58) | ALDH1A1SMN1; SMN2PKMHPGDNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007066099-A1 | PYRIMIDINE DERIVATIVES | ASTRAZENECA AB (SE) | 2007-06-14 | — | — | WO | disclosed |
| WO-2007066103-A1 | PYRIMIDINE DERIVATIVES AS CLASS I PI3K INHIBITOR | ASTRAZENECA AB (SE) | 2007-06-14 | — | — | WO | disclosed |
| EP-1512692-A2 | Novel inhibitors of prenylated pyrophosphate consuming enzymes | Universiteit Leiden (NL) | 2005-03-09 | — | — | EP | disclosed |
| US-20040121941-A1 | Novel inhibitors of prenylated pyrophosphate consuming enzymes | RIJKSUNIVERSITEIT LEIDEN (NL) | 2004-06-24 | — | — | US | disclosed |
| US-6624147-B1 | Inhibiting protein:prenyl transferases, such as protein:geranylgeranyl transferase-1, and other prenyl pyrophosphate-consuming enzymes such as squalene synthase and geranylgeranyl pyrophosphate synthase are disclosed. | RIJKSUNIVERSITEIT LEIDEN (NL) | 2003-09-23 | — | — | US | disclosed |
| EP-1090909-A1 | Novel inhibitors of prenylated pyrophosphate consuming enzymes | RIJKSUNIVERSITEIT LEIDEN (NL) | 2001-04-11 | — | — | EP | disclosed |