Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 10/20 | 0.48 |
| ▸ | MAPK14 | Q16539 | 4/20 | 0.35 |
| ▸ | CSNK1D | P48730 | 2/20 | 0.35 |
| ▸ | JAK3 | P52333 | 1/20 | 0.35 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.34 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.34 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.34 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.33 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.33 |
| ▸ | BRAF | P15056 | 1/20 | 0.32 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.32 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.32 |
| ▸ | CDK2 | P24941 | 1/20 | 0.32 |
| ▸ | CDK9 | P50750 | 1/20 | 0.32 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.32 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.32 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5138811 | 0.89 | TGFBR1 (0.49) | TGFBR1MAPK14ADORA2AADORA1BRAF | |
| SCHEMBL5138513 | 0.88 | TGFBR1 (0.49) | TGFBR1MAPK14ADORA2AADORA1BRAF | |
| SCHEMBL5139156 | 0.86 | TGFBR1 (0.47) | TGFBR1MAPK14ADORA2AADORA1BRAF | |
| SCHEMBL5138562 | 0.84 | TGFBR1 (0.46) | TGFBR1MAPK14BRAFCCNA2CDK2 | |
| SCHEMBL4339418 | 0.80 | TGFBR1 (0.49) | TGFBR1MAPK14RIPK2KDRACVR1B | |
| SCHEMBL5315992 | 0.80 | PIK3CA (0.36) | TGFBR1MAPK14PIK3CAHCRTR1HCRTR2 | |
| SCHEMBL5138940 | 0.78 | TGFBR1 (0.53) | TGFBR1MAPK14CSNK1DJAK3ADORA2A | |
| SCHEMBL4337360 | 0.76 | TGFBR1 (0.81) | TGFBR1MAPK14CSNK1DKDM4EALDH1A1 | |
| SCHEMBL5138494 | 0.76 | TGFBR1 (0.46) | TGFBR1MAPK14PIK3CABRAF | |
| SCHEMBL5139923 | 0.76 | TGFBR1 (0.47) | TGFBR1MAPK14CCNA2CDK2CCNA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1786802-A1 | PYRIMIDINYLIMIDAZOLES AS TGF-BETA INHIBITORS | Biogen Idec MA, Inc. (US) | 2007-05-23 | — | — | EP | disclosed |
| WO-2006026306-A1 | PYRIMIDINYLIMIDAZOLES AS TGF-BETA INHIBITORS | BIOGEN IDEC MA INC. (US) | 2006-03-09 | — | — | WO | disclosed |